Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 2/20 | 0.48 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CDK2 | P24941 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | PI4KA | P42356 | 2/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1081384 | 0.76 | CDC7 (0.55) | CDC7DBF4EGFRCSF1RLMNA | |
| SCHEMBL5829618 | 0.73 | JAK2 (0.33) | LMNATSHRMAPK1CYP1A2CDK2 | |
| SCHEMBL2938675 | 0.70 | AKT2 (0.70) | CDC7DBF4EGFRCSF1RAKT2 | |
| SCHEMBL5998976 | 0.68 | HIF1A (0.48) | CDC7DBF4EGFRCSF1RLMNA | |
| SCHEMBL1060507 | 0.67 | MKNK1 (0.72) | EGFRLMNATSHRMAPK1CYP1A2 | |
| SCHEMBL796398 | 0.67 | CDC7 (0.72) | CDC7DBF4EGFRCSF1RLMNA | |
| SCHEMBL29001527 | 0.67 | CDC7 (0.48) | CDC7DBF4EGFRCSF1RLMNA | |
| SCHEMBL5384434 | 0.67 | CDC7 (0.59) | CDC7DBF4EGFRCSF1RLMNA | |
| SCHEMBL5808903 | 0.66 | SMN1; SMN2 (0.57) | CDC7DBF4EGFRCSF1RLMNA | |
| SCHEMBL8707168 | 0.66 | LMNA (0.62) | CDC7DBF4EGFRCSF1RLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673439-A2 | METHODS FOR ALTERING MRNA SPLICING AND TREATING FAMILIAL DYSAUTONOMIA AND OTHER MECHANISTICALLY RELATED DISORDERS | THE GENERAL HOSPITAL CORPORATION (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005033290-A2 | METHODS FOR ALTERING MRNA SPLICING AND TREATING FAMILIAL DYSAUTONOMIA AND OTHER MECHANISTICALLY RELATED DISORDERS | THE GENERAL HOSPITAL CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |