Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.31 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1081382 | 0.76 | LMNA (0.38) | JAK2HSD17B10HPGDDPP4LMNA | |
| SCHEMBL5829620 | 0.73 | CDC7 (0.48) | HSD17B10ALDH1A1HPGDLMNAMAPK1 | |
| SCHEMBL2938674 | 0.70 | JAK2 (0.54) | JAK2KDM4EHSD17B10ALDH1A1GAA | |
| Biphenyl SCHEMBL19716178 | 0.69 | MAP4K4 (0.44) | JAK2KDM4EDPP4LMNACYP3A4 | |
| SCHEMBL891009 | 0.68 | TTBK1 (0.57) | KDM4EHSD17B10ALDH1A1HPGDLMNA | |
| SCHEMBL2623130 | 0.67 | TRPA1 (0.58) | ALDH1A1HPGDCYP1A2TSHRTTBK1 | |
| SCHEMBL5384430 | 0.67 | LMNA (0.40) | HSD17B10LMNAMAPK1CYP1A2CYP2D6 | |
| SCHEMBL796397 | 0.67 | LMNA (0.44) | JAK2KDM4EHSD17B10ALDH1A1GLA | |
| SCHEMBL5808902 | 0.66 | SMN1; SMN2 (0.42) | KDM4EHSD17B10ALDH1A1HPGDLMNA | |
| SCHEMBL6663881 | 0.66 | MEN1 (0.47) | KDM4EALDH1A1GLAHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673439-A2 | METHODS FOR ALTERING MRNA SPLICING AND TREATING FAMILIAL DYSAUTONOMIA AND OTHER MECHANISTICALLY RELATED DISORDERS | THE GENERAL HOSPITAL CORPORATION (US) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005033290-A2 | METHODS FOR ALTERING MRNA SPLICING AND TREATING FAMILIAL DYSAUTONOMIA AND OTHER MECHANISTICALLY RELATED DISORDERS | THE GENERAL HOSPITAL CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |