Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5829983 | 1.00 | KDM4E (0.41) | KDM4ERAB9ANPC1MAPK1NPSR1 | |
| SCHEMBL5456414 | 0.78 | MAPK11 (0.60) | — | |
| SCHEMBL7248577 | 0.76 | MAPK14 (0.52) | KDM4ERAB9ANPC1MAPK1ALDH1A1 | |
| SCHEMBL7250809 | 0.75 | AKR1C3 (0.46) | RAB9ACYP3A4CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL5829519 | 0.71 | CYP17A1 (0.51) | RAB9ANPC1MAPK1NPSR1CYP3A4 | |
| SCHEMBL5452258 | 0.69 | MAPK14 (0.48) | — | |
| SCHEMBL6310322 | 0.67 | RAB9A (0.50) | KDM4ERAB9ANPC1TP53HPGD | |
| SCHEMBL14519748 | 0.66 | MAPK14 (0.48) | — | |
| SCHEMBL6337994 | 0.65 | MELK (0.51) | MEN1KMT2AMAPTDRD2 | |
| SCHEMBL11765733 | 0.65 | NPC1 (0.68) | KDM4ERAB9ANPC1MAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071198-B1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION (US) | 2006-07-04 | — | — | US | disclosed |