Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 3/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.42 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7248577 | 0.87 | MAPK14 (0.52) | MELKKMT2AMAPK14MAPK11CSNK1D | |
| SCHEMBL5829487 | 0.87 | ALDH1A1 (0.51) | MELKBRAFKMT2AMAPK14MAPK11 | |
| SCHEMBL6338216 | 0.79 | GRIA1 (0.47) | SRCBRAFKDRMAPT | |
| SCHEMBL5829519 | 0.72 | CYP17A1 (0.51) | MEN1KMT2AMAPK14MAPK11MAPT | |
| SCHEMBL7250809 | 0.70 | AKR1C3 (0.46) | BRAFMEN1KMT2AMAPTDRD2 | |
| SCHEMBL5829385 | 0.69 | SRC (0.54) | SRCBRAFKDRMEN1KMT2A | |
| SCHEMBL5463406 | 0.69 | ROCK2 (0.44) | MELKBRAFMAPK14MAPK11CSNK1D | |
| SCHEMBL28337260 | 0.69 | MELK (0.69) | MELKMEN1KMT2AMAPTRPS6KA3 | |
| SCHEMBL5255877 | 0.68 | MAPK14 (0.78) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL1375430 | 0.68 | LMNA (0.73) | MEN1KMT2AMAPTRPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6979686-B1 | Substituted pyrazoles as p38 kinase inhibitors | PHARMACIA CORPORATION (US) | 2005-12-27 | — | — | US | disclosed |