Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | AGO2 | Q9UKV8 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aniline SCHEMBL5693989 | 0.95 | TSHR (0.55) | TSHRALDH1A1NT5EKMT2ATDP1 | |
| Aniline SCHEMBL167327 | 0.87 | TSHR (0.65) | TSHRALDH1A1NT5EKMT2ATDP1 | |
| Aniline SCHEMBL676147 | 0.87 | TSHR (0.65) | TSHRALDH1A1NT5EKMT2ATDP1 | |
| Aniline SCHEMBL167326 | 0.87 | TSHR (0.65) | TSHRALDH1A1NT5EKMT2ATDP1 | |
| Aniline SCHEMBL28037884 | 0.84 | TSHR (0.61) | TSHRALDH1A1NT5EKMT2ATDP1 | |
| Aniline SCHEMBL28037885 | 0.84 | TSHR (0.61) | TSHRALDH1A1NT5EKMT2ATDP1 | |
| Aniline SCHEMBL5693986 | 0.84 | TSHR (0.61) | TSHRALDH1A1NT5EKMT2ATDP1 | |
| Aniline SCHEMBL3156113 | 0.84 | TSHR (0.61) | TSHRALDH1A1NT5EKMT2ATDP1 | |
| Aniline SCHEMBL8067192 | 0.84 | TSHR (0.61) | TSHRALDH1A1NT5EKMT2ATDP1 | |
| Aniline SCHEMBL11412410 | 0.82 | TSHR (0.58) | TSHRALDH1A1NT5EKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0063270-B1 | PROCESS FOR PREPARING P-SULFANILIC ACID | BAYER AG (DE) | 1985-01-02 | — | — | EP | claimed |
| US-7034100-B2 | Heterogeneous reaction method for preparing functionalized polyanilines | NATIONAL TSING HUA UNIVERSITY (TW) | 2006-04-25 | — | — | US | disclosed |
| US-20020081275-A1 | Heterogeneous reaction method for preparing functionalized polyanilines | NATIONAL TSING HUA UNIVERSITY (TW) | 2002-06-27 | — | — | US | disclosed |
| US-6380346-B1 | HIGH SOLUBILITY AND/OR HIGH PROCESSIBILITY; TREATMENT WITH A SOLUTION OF REACTIVE CHEMICAL REAGENT(S), E.G. MERCAPTAN, IN A SELECTED SOLVENT; FUNCTIONALIZING THE SOLID POLYANILINE AND TRANSFORMING THE BACKBONE INTO A MORE REDUCED FORM | NATIONAL TSING HUA UNIVERSITY (TW) | 2002-04-30 | — | — | US | disclosed |
| EP-0063270-A1 | Process for preparing p-sulfanilic acid | BAYER AG (DE) | 1982-10-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020081275-A1 | Heterogeneous reaction method for preparing functionalized polyanilines | PARG, TET2, ROS1 | TSHR 3876/4885ALDH1A1 2186/4885NT5E 3342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.