Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aniline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | MPO | P05164 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 5/20 | 0.46 |
| ▸ | CA2 | P00918 | 5/20 | 0.46 |
| ▸ | CA9 | Q16790 | 5/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CA4 | P22748 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aniline SCHEMBL28037885 | 0.94 | TSHR (0.61) | TSHRKMT2ALMNACYP3A4HTR6 | |
| Aniline SCHEMBL5693989 | 0.90 | TSHR (0.55) | TSHRKMT2ALMNACYP3A4HTR6 | |
| Aniline SCHEMBL9280598 | 0.89 | TSHR (0.48) | TSHRKMT2ALMNACYP3A4HTR6 | |
| Aniline SCHEMBL28486286 | 0.85 | HTR6 (0.52) | TSHRKMT2ALMNACYP3A4HTR6 | |
| Aniline SCHEMBL29211863 | 0.85 | TSHR (0.50) | TSHRKMT2ALMNACYP3A4HTR6 | |
| Aniline SCHEMBL5831365 | 0.84 | TSHR (0.55) | TSHRKMT2ALMNACYP3A4HTR6 | |
| Aniline SCHEMBL4582474 | 0.82 | TSHR (0.69) | TSHRKMT2ALMNACYP3A4HTR6 | |
| Aniline SCHEMBL167326 | 0.80 | TSHR (0.65) | TSHRKMT2ALMNACYP3A4HTR6 | |
| Aniline SCHEMBL10500825 | 0.80 | TSHR (0.65) | TSHRKMT2ALMNACYP3A4HTR6 | |
| Aniline SCHEMBL676147 | 0.80 | TSHR (0.65) | TSHRKMT2ALMNACYP3A4HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115627496-A | Preparation method of cobalt-nickel-based electrochemical hydrogen evolution reaction self-supporting electrode coated with polyaniline through electrodeposition | 南京航空航天大学 | 2023-01-20 | — | — | CN | claimed |
| CN-115627496-A | Preparation method of cobalt-nickel-based electrochemical hydrogen evolution reaction self-supporting electrode coated with polyaniline through electrodeposition | 南京航空航天大学 | 2023-01-20 | — | — | CN | disclosed |
| US-6037458-A | REMOVING APOLIPOPROTEINS FROM BODY FLUID IN A HUMAN SUFFERING FROM AMYLOIDOSIS; PASSING BODY FLUID THROUGH CONTAINER HAVING A FLUID INLET AND A FLUID OUTLET PACKED WITH AN ADSORBENT, RETURNING BODY FLUID PURFIED OF APOLIPROTEINS TO MAMMAL | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2000-03-14 | — | — | US | disclosed |
| US-5216127-A | Mixing body fluid containing serum amuloid protein with absorbent of water insoluble carrier and an amine, filtration and recovering protein | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1993-06-01 | — | — | US | disclosed |
| EP-0321703-B1 | ABSORBENT FOR SERUM AMYLOID PROTEIN | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1993-04-28 | — | — | EP | disclosed |
| EP-0476721-A2 | A method for removing serum amyloid protein | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1992-03-25 | — | — | EP | disclosed |
| EP-0321703-A1 | Absorbent for serum amyloid protein | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-06-28 | — | — | EP | disclosed |