Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.64 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.64 |
| ▸ | DRD2 | P14416 | 6/20 | 0.60 |
| ▸ | DRD3 | P35462 | 5/20 | 0.60 |
| ▸ | ACHE | P22303 | 5/20 | 0.60 |
| ▸ | CA1 | P00915 | 4/20 | 0.60 |
| ▸ | CA2 | P00918 | 4/20 | 0.60 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5833494 | 1.00 | MTNR1A (0.64) | MTNR1AMTNR1BDRD2DRD3ACHE | |
| SCHEMBL5833214 | 1.00 | MTNR1A (0.64) | MTNR1AMTNR1BDRD2DRD3ACHE | |
| SCHEMBL8056603 | 0.81 | DRD2 (0.68) | MTNR1AMTNR1BDRD2DRD3ACHE | |
| SCHEMBL8056606 | 0.81 | DRD2 (0.68) | MTNR1AMTNR1BDRD2DRD3ACHE | |
| SCHEMBL8056611 | 0.81 | DRD2 (0.68) | MTNR1AMTNR1BDRD2DRD3ACHE | |
| Hydrochloric Acid SCHEMBL10853587 | 0.80 | DRD2 (0.66) | MTNR1AMTNR1BDRD2DRD3ACHE | |
| SCHEMBL3854031 | 0.78 | MTNR1A (1.00) | MTNR1AMTNR1BDRD2DRD3ACHE | |
| Hydrochloric Acid SCHEMBL7926433 | 0.76 | MTNR1A (0.55) | MTNR1AMTNR1BCA1CA2GRIN2B | |
| Hydrochloric Acid SCHEMBL11494181 | 0.76 | DRD2 (0.78) | MTNR1AMTNR1BDRD2DRD3ACHE | |
| SCHEMBL2701521 | 0.75 | DRD2 (1.00) | MTNR1AMTNR1BDRD2DRD3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049337-B2 | Derivatives of 2-aminotetralins and pharmaceutical analogs thereof exhibiting differential CNS receptor activity and behavior | WAYNE STATE UNIVERSITY (US) | 2006-05-23 | — | — | US | disclosed |
| US-20030225154-A1 | Derivatives of 2-aminotetralins and pharmaceutical analogs thereof exhibiting differentail cns receptor activity and behavior | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-12-04 | — | — | US | disclosed |
| WO-2001089453-A2 | DERIVATIVES OF 2-AMINOTETRALINS AND PHARMACEUTICAL ANALOGS THEREOF EXHIBITING DIFFERENTIAL CNS RECEPTOR ACTIVITY AND BEHAVIOR | WAYNE STATE UNIVERSITY (US) | 2001-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225154-A1 | Derivatives of 2-aminotetralins and pharmaceutical analogs thereof exhibiting differentail cns receptor activity and behavior | HTR3B, HTR7, HTR6 | MTNR1A 25/4885MTNR1B 22/4885DRD2 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.