Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 14/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24264985 | 0.81 | WDR5 (0.63) | WDR5LMNANPC1RAB9AGAA | |
| Hydrochloric Acid SCHEMBL30309713 | 0.81 | ALDH1A1 (0.63) | WDR5LMNANPC1RAB9AGAA | |
| SCHEMBL5833790 | 0.79 | KMT2A (0.52) | LMNANPC1RAB9AGAAKMT2A | |
| SCHEMBL10750669 | 0.78 | WDR5 (0.53) | WDR5LMNANPC1RAB9AGAA | |
| SCHEMBL10749506 | 0.77 | WDR5 (0.60) | WDR5LMNANPC1RAB9AGAA | |
| SCHEMBL10748933 | 0.75 | WDR5 (0.51) | WDR5LMNANPC1RAB9AGAA | |
| SCHEMBL5313033 | 0.73 | RAB9A (0.68) | LMNANPC1RAB9AGAAKMT2A | |
| SCHEMBL10749623 | 0.73 | WDR5 (0.46) | WDR5LMNANPC1RAB9AGAA | |
| SCHEMBL10747230 | 0.73 | WDR5 (0.46) | WDR5LMNANPC1RAB9AGAA | |
| SCHEMBL14668861 | 0.73 | ERN1 (0.48) | LMNANPC1RAB9AGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105533-B2 | Fused heterobicyclo substituted phenyl metabotropic glutamate-5 modulators | MERCK & CO., INC. (US) | 2006-09-12 | — | — | US | disclosed |
| US-20050240021-A1 | Fused heterobicyclo substituted phenyl metabotropic glutamate-5 modulators | MERCK SHARP & DOHME CORP. | 2005-10-27 | — | — | US | disclosed |
| WO-2004024074-A2 | FUSED HETEROBICYCLO SUBSTITUTED PHENYL METABOTROPIC GLUTAMATE-5 MODULATORS | MERCK & CO., INC. (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050240021-A1 | Fused heterobicyclo substituted phenyl metabotropic glutamate-5 modulators | GRM5, GRIK5, GRM1 | WDR5 688/4885LMNA 4815/4885NPC1 2493/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.