Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 7/20 | 0.35 |
| ▸ | MAOB | P27338 | 5/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | SDHA | P31040 | 2/20 | 0.34 |
| ▸ | CALML3 | P27482 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5834076 | 0.82 | MAOA (0.30) | MAOA | |
| SCHEMBL6765854 | 0.78 | CYP2E1 (0.35) | CYP2E1MAOAMAOBPTGS1SDHA | |
| SCHEMBL5833559 | 0.70 | F10 (0.42) | CYP2E1MAOAMAOBPTGS1SDHA | |
| SCHEMBL5845072 | 0.68 | MAOA (0.36) | MAOAMAOBPTGS1SDHACALML3 | |
| SCHEMBL6426468 | 0.65 | MAOB (0.45) | MAOAMAOBPTGS1SDHACALML3 | |
| SCHEMBL6426472 | 0.65 | MAOB (0.45) | MAOAMAOBPTGS1SDHACALML3 | |
| SCHEMBL5834248 | 0.65 | MAOA (0.49) | CYP2E1MAOAMAOBPTGS1SDHA | |
| SCHEMBL10152915 | 0.64 | MAOB (0.44) | MAOAMAOBPTGS1SDHACALML3 | |
| SCHEMBL5833725 | 0.63 | MAOA (0.43) | MAOAMAOBPTGS1SDHACALML3 | |
| SCHEMBL5834079 | 0.63 | CALML3 (0.37) | MAOAMAOBPTGS1SDHACALML3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7087629-B2 | Useful activity against Gram-positive pathogens and, in particular, against various strains exhibiting resistance to vancomycin and against E. faecium strains resistant to both aminoglycosides and clinically used beta-lactams | ASTRAZENECA AB (SE) | 2006-08-08 | — | — | US | disclosed |