SCHEMBL583457

SCHEMBL583457

CSCC[C@H](N)C(=O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MARS1 P56192 6/20 1.00
DOT1L Q8TEK3 5/20 0.67
CARM1 Q86X55 5/20 0.67
NSD2 O96028 4/20 0.67
SETD7 Q8WTS6 4/20 0.67
EHMT2 Q96KQ7 3/20 0.67
NNMT P40261 3/20 0.67
PRMT1 Q99873 3/20 0.67
EZH2 Q15910 2/20 0.67
TRDMT1 O14717 2/20 0.67
PRMT5 O14744 2/20 0.67
INMT O95050 2/20 0.67
METTL3 Q86U44 2/20 0.67
EHMT1 Q9H9B1 2/20 0.67
METTL14 Q9HCE5 2/20 0.67
FASN P49327 2/20 0.67
SUV39H1 O43463 1/20 0.67
PRMT3 O60678 1/20 0.67
PNMT P11086 1/20 0.67
DNMT1 P26358 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3014292 1.00 MARS1 (1.00) MARS1DOT1LCARM1NSD2SETD7
Sulfuric Acid SCHEMBL28535358 0.97 MARS1 (0.93) MARS1DOT1LCARM1NSD2SETD7
SCHEMBL28544526 0.93 MARS1 (0.86) MARS1DOT1LCARM1NSD2SETD7
SCHEMBL5582866 0.91 MARS1 (0.84) MARS1DOT1LCARM1NSD2SETD7
SCHEMBL28606779 0.90 MARS1 (0.81) MARS1DOT1LCARM1NSD2SETD7
SCHEMBL6408975 0.89 MARS1 (0.80) MARS1DOT1LCARM1NSD2SETD7
SCHEMBL6408983 0.89 MARS1 (0.80) MARS1DOT1LCARM1NSD2SETD7
SCHEMBL8749425 0.88 MARS1 (0.79) MARS1DOT1LCARM1NSD2SETD7
SCHEMBL28606778 0.87 MARS1 (0.76) MARS1DOT1LCARM1NSD2SETD7
Adenosine Phosphate SCHEMBL15670771 0.87 EZH2 (0.80) MARS1DOT1LCARM1NSD2SETD7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 246 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117164655-A Stable decarboxylated S-adenosine-L-methionine analogue and application thereof 天津大学 2023-12-05 CN claimed
CN-116840197-A 2' -O-methyltransferase activity detection method, kit and application 中国科学院苏州生物医学工程技术研究所 2023-10-03 CN claimed
CN-115820443-A Saccharomyces cerevisiae engineering bacterium for high yield of S-adenosine-L-methionine and application thereof 浙江工业大学 2023-03-21 CN claimed
CN-112852691-B Recombinant escherichia coli producing MK-7 and construction method and application thereof 中国科学院微生物研究所 2022-09-16 CN claimed
CN-112048515-B Rape S-adenosine-L-methionine dependent methyltransferase gene BnPMT6 and application thereof 华中农业大学 2022-09-13 CN claimed
EP-3996668-A1 TOPICAL COMPOSITIONS AND METHODS OF USING SAME AGAINST MITOCHONDRIAL FRAGMENTATION Unilever Global IP Limited (GB) 2022-05-18 EP claimed
CN-112899297-A Method for producing synephrine based on catalysis of phenylethanolamine-N-methyltransferase 南京工业大学 2021-06-04 CN claimed
CN-112852691-A Recombinant escherichia coli producing MK-7 and construction method and application thereof 中国科学院微生物研究所 2021-05-28 CN claimed
CN-112710767-A Tandem mass spectrometry kit for measuring NNMT catalytic substrate and NNMT catalytic product 浙江大学 2021-04-27 CN claimed
CN-109021056-B Farnesoid X receptor agonists 博瑞生物医药(苏州)股份有限公司 2021-03-09 CN claimed
CN-1665554-A Compounds and method for coating surfaces in a haemocompatible manner HEMOTEQ GMBH (DE) 2005-09-07 CN claimed
CN-1638650-A Composition improving age-related physiological deficits and increasing longevity NESTLE SA (CH) 2005-07-13 CN claimed
CN-1560610-A Homotypic cysteine measuring method and its reagent 王学忠 2005-01-05 CN claimed
EP-0482493-B1 Pharmaceutical compositions active in the therapy of neurological affections in aids patients, containing as an active principle at least S-adenosyl-L-methionine salt. KNOLL FARMACEUTICI S P A (IT) 2001-02-28 EP claimed
CN-1207683-A Potentiators of endogenous production of cytokines and hematopoietic factors and methods of use thereof M·B·巴拉佐夫斯基 1999-02-10 CN claimed
CN-1102324-A Pharmaceutical composition FUJI CHEM IND CO LTD (JP) 1995-05-10 CN claimed
EP-0516660-B1 USE OF S-ADENOSYL METHIONINE AS AN AGENT AGAINST VIRAL INFECTIONS BY RETROVIRUSES Grundmann, Ewald, Dr. (DE) 1993-08-18 EP claimed
CN-1012819-B Method for preparing stable salt of S-adenosine-L-methionine and polyanion GIBIPHARMA SPA (IT) 1991-06-12 CN claimed
CN-85107218-A The preparation method and the application thereof of the stable salt of S-adenosine-L-methionine(Met) and polyanion 1986-09-03 CN claimed
EP-0084169-B1 METHOD FOR THE ORAL ADMINISTRATION OF SUBSTANCES IN THE FORM OF LIPOSOMES, AND RELATIVE PHARMACEUTICAL COMPOSITIONS AUSONIA FARMACEUTICI S.r.l. (IT) 1985-09-04 EP claimed