SCHEMBL5835

SCHEMBL5835

O=C(O)Cc1ccc(Br)cc1F

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 11/20 0.52
MEN1 O00255 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP2C9 P11712 1/20 0.51
KMT2A Q03164 1/20 0.51
HSD17B10 Q99714 1/20 0.51
PDPK1 O15530 1/20 0.49
DGAT1 O75907 1/20 0.47
AKR1A1 P14550 2/20 0.43
P2RX7 Q99572 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29574729 1.00 AKR1B1 (0.52) AKR1B1MEN1CYP1A2CYP2C9KMT2A
SCHEMBL135166 0.85 PTGDR2 (0.44) AKR1B1MEN1CYP1A2CYP2C9KMT2A
SCHEMBL29738013 0.84 AKR1B1 (0.52) AKR1B1MEN1CYP1A2CYP2C9KMT2A
SCHEMBL6456130 0.84 AKR1B1 (0.52) AKR1B1MEN1CYP1A2CYP2C9KMT2A
SCHEMBL8444 0.83 DGAT1 (0.46) AKR1B1MEN1CYP1A2CYP2C9KMT2A
SCHEMBL29574602 0.83 DGAT1 (0.46) AKR1B1MEN1CYP1A2CYP2C9KMT2A
SCHEMBL8696600 0.83 DGAT1 (0.46) AKR1B1MEN1CYP1A2CYP2C9KMT2A
SCHEMBL538344 0.83 DGAT1 (0.55) AKR1B1MEN1CYP1A2CYP2C9KMT2A
SCHEMBL16070101 0.83 DGAT1 (0.46) AKR1B1MEN1CYP1A2CYP2C9KMT2A
SCHEMBL31551664 0.83 DGAT1 (0.55) AKR1B1MEN1CYP1A2CYP2C9KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 411 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122059906-A Compounds for inhibiting PTPN proteins and uses thereof 艾斯拓康生物医药(天津)有限公司 2026-05-19 CN disclosed
CN-122010871-A Compounds for inhibiting PTPN proteins and uses thereof 艾斯拓康生物医药(天津)有限公司 2026-05-12 CN disclosed
US-20260124309-A1 STAT6 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-05-07 US disclosed
EP-4271674-B9 CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2026-03-11 EP disclosed
US-12570642-B2 GLP-IR modulating compounds GILEAD SCIENCES, INC. (US) 2026-03-10 US disclosed
EP-4695240-A2 CYCLIC VINYL SULFONE WRN INHIBITORS Nimbus Wadjet, Inc. (US) 2026-02-18 EP disclosed
EP-4691554-A2 GLP-1R MODULATING COMPOUNDS Gilead Sciences, Inc. (US) 2026-02-11 EP disclosed
US-12516041-B2 Crystal forms of GLP-1R agonists and uses thereof QILU REGOR THERAPEUTICS INC. (CN) 2026-01-06 US disclosed
US-12497382-B2 GLP-1R modulating compounds GILEAD SCIENCES, INC. (US) 2025-12-16 US disclosed
EP-4271674-B3 CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS GILEAD SCIENCES INC (US) 2025-12-03 EP disclosed
WO-2004074270-A2 INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME PFIZER INC. (US) 2004-09-02 WO disclosed
EP-1077701-A4 ANTI-VIRAL COMPOUNDS LILLY CO ELI (US) 2002-03-20 EP disclosed
CN-1292697-A Anti-viral compound LILLY CO ELI (US) 2001-04-25 CN disclosed
EP-1077701-A1 ANTI-VIRAL COMPOUNDS ELI LILLY AND COMPANY (US) 2001-02-28 EP disclosed
WO-1999059587-A1 ANTI-VIRAL COMPOUNDS ELI LILLY AND COMPANY (US) 1999-11-25 WO disclosed
EP-0874826-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1998-11-04 EP disclosed
US-5827863-A Pyrazole derivatives as angiotensin II antagonists J. URIACH & CIA, S.A. (ES) 1998-10-27 US disclosed
WO-1997024331-A1 NAPHTHALENE QUINOLINES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION LABORATORIOS MENARINI S.A. (ES) 1997-07-10 WO disclosed
EP-0721454-A1 NEW PYRAZOLE DERIVATIVES AS ANGIOTENSIN II ANTAGONIST J. URIACH & CIA. S.A. (ES) 1996-07-17 EP disclosed
WO-1996004273-A1 NEW PYRAZOLE DERIVATIVES AS ANGIOTENSIN II ANTAGONIST J. URIACH & CIA, S.A. (ES) 1996-02-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124309-A1 STAT6 DEGRADERS AND USES THEREOF STAT6, NCOR2, NCOR1 AKR1B1 501/4885MEN1 4497/4885CYP1A2 780/4885
US-12570642-B2 GLP-IR modulating compounds GLP1R, GIPR, GPR119 AKR1B1 1692/4885MEN1 1820/4885CYP1A2 3776/4885
US-12497382-B2 GLP-1R modulating compounds GLP1R, GIPR, GPR119 AKR1B1 2682/4885MEN1 1966/4885CYP1A2 4719/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.