Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6819356 | 0.80 | TRPV4 (0.41) | TRPV4LRRK2HTR2AHTR2CKDM4E | |
| SCHEMBL31075362 | 0.80 | TRPV4 (0.41) | TRPV4LRRK2HTR2AHTR2CKDM4E | |
| SCHEMBL2496224 | 0.77 | TRPV4 (0.60) | TRPV4HTR2AHTR2CKDM4EALDH1A1 | |
| SCHEMBL29709827 | 0.77 | TRPV4 (0.60) | TRPV4HTR2AHTR2CKDM4EALDH1A1 | |
| SCHEMBL4477338 | 0.76 | TRPV4 (0.54) | TRPV4GAAKMT2ANFE2L2 | |
| SCHEMBL3369690 | 0.76 | TRPV4 (0.50) | TRPV4HTR2AHTR2CKDM4EALDH1A1 | |
| SCHEMBL7222182 | 0.73 | TRPV4 (0.50) | TRPV4ALDH1A1MEN1KMT2ACA12 | |
| SCHEMBL5835958 | 0.73 | TRPV4 (0.56) | TRPV4KDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL5835370 | 0.73 | TRPV4 (0.52) | TRPV4KDM4EALDH1A1GAAMAPK1 | |
| SCHEMBL13517584 | 0.73 | TRPV4 (0.52) | TRPV4KDM4EALDH1A1GAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026349-B2 | Sulfonamides | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-11 | — | — | US | disclosed |