Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | CCNH | P51946 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2003288 | 0.76 | TRPV4 (0.60) | TRPV4PKMRAB9AHSD11B1CNR2 | |
| SCHEMBL30161661 | 0.76 | TRPV4 (0.60) | TRPV4PKMRAB9AHSD11B1CNR2 | |
| SCHEMBL3410514 | 0.76 | TRPV4 (0.47) | TRPV4PKMRAB9ACNR2SLC22A12 | |
| SCHEMBL5835086 | 0.73 | TRPV4 (0.46) | TRPV4CA12CA1CA2CA4 | |
| SCHEMBL30161536 | 0.72 | TRPV4 (0.47) | TRPV4CA12CA1CA2CA4 | |
| SCHEMBL534192 | 0.72 | TRPV4 (0.47) | TRPV4CA12CA1CA2CA4 | |
| SCHEMBL941069 | 0.72 | TRPV4 (0.47) | TRPV4MEN1KMT2AHSD11B1TSHR | |
| SCHEMBL30395525 | 0.72 | TRPV4 (0.60) | TRPV4CA12CA1CA2CA4 | |
| SCHEMBL4617448 | 0.72 | TRPV4 (0.47) | TRPV4CA12CA1CA2CA4 | |
| SCHEMBL30161533 | 0.72 | TRPV4 (0.47) | TRPV4MEN1KMT2AHSD11B1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660751-B1 | Sulfonamide derivatives as 5-HT7 receptor antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-12-09 | — | — | US | disclosed |
| EP-1163221-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-12-19 | — | — | EP | disclosed |
| WO-2000056712-A1 | SULFONAMIDE DERIVATIVES AS 5-HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2000-09-28 | — | — | WO | disclosed |