Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10084516 | 0.83 | SMN1; SMN2 (0.62) | MAPK1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL27751166 | 0.76 | LMNA (0.69) | MAPK1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4875670 | 0.76 | SMN1; SMN2 (0.69) | MAPK1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL10084297 | 0.74 | TSHR (0.52) | MAPK1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL91510 | 0.73 | MEN1 (0.53) | MAPK1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4873516 | 0.73 | MAPK1 (0.56) | MAPK1SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL7817138 | 0.73 | CYP4F2 (0.54) | MAPK1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL129801 | 0.72 | CYP4F2 (0.71) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL91587 | 0.72 | MAPK1 (0.63) | MAPK1SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL9153870 | 0.72 | MAPK1 (0.55) | MAPK1SMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| EP-1124810-A1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026202-A1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-05-11 | — | — | WO | disclosed |