SCHEMBL583582

SCHEMBL583582

O=C(O)C1CCCC2(CCCO2)C1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.39
GRM2 Q14416 2/20 0.39
GRM3 Q14832 2/20 0.39
GRM4 Q14833 2/20 0.39
ALOX15 P16050 2/20 0.39
MTOR P42345 2/20 0.39
CYP2C19 P33261 2/20 0.39
TSHR P16473 2/20 0.39
CYP1A2 P05177 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
GRM8 O00222 1/20 0.39
GRM6 O15303 1/20 0.39
GRM5 P41594 1/20 0.39
GRM1 Q13255 1/20 0.39
PLCB1 Q9NQ66 1/20 0.39
OPRK1 P41145 6/20 0.38
OPRD1 P41143 3/20 0.38
OPRM1 P35372 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL583655 0.94 ALOX15 (0.44) LMNAGRM2GRM3GRM4ALOX15
SCHEMBL31119101 0.87 ALOX15 (0.40) LMNAGRM2GRM3GRM4ALOX15
SCHEMBL30148928 0.86 CYP2C19 (0.44) LMNAGRM2GRM3GRM4ALOX15
SCHEMBL19304 0.82 TSHR (0.38) LMNAGRM2GRM3GRM4ALOX15
SCHEMBL10773163 0.79 GRM2 (0.37) LMNAGRM2GRM3GRM4ALOX15
SCHEMBL16635812 0.78 SLC6A12 (0.39) LMNAGRM4ALOX15MTORCYP2C19
SCHEMBL6682030 0.78 OPRK1 (0.36) LMNAGRM2GRM3GRM4ALOX15
SCHEMBL28710315 0.76 TSHR (0.48) LMNAGRM2GRM3GRM4ALOX15
SCHEMBL7878595 0.76 ALDH1A1 (0.41) LMNAALOX15MTORCYP2C19OPRK1
SCHEMBL30148920 0.76 CYP2C19 (0.50) LMNAGRM2GRM3GRM4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017060854-A1 BIARYL PYRAZOLES AS NRF2 REGULATORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2017-04-13 WO disclosed
EP-2632436-A1 SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT Abbvie Inc. (US) 2013-09-04 EP disclosed
EP-2613769-A1 MELT-EXTRUDED SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT Abbvie Inc. (US) 2013-07-17 EP disclosed
EP-2576546-A1 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES Abbvie Inc. (US) 2013-04-10 EP disclosed
WO-2012121758-A1 MELT-EXTRUDED SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT ABBVIE INC. (US) 2012-09-13 WO disclosed
WO-2012058392-A1 SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT ABBOTT LABORATORIES (US) 2012-05-03 WO disclosed
EP-2417138-A1 PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS Schering Corporation (US) 2012-02-15 EP disclosed
WO-2011149492-A1 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES ABBOTT LABORATORIES (US) 2011-12-01 WO disclosed
WO-2010118207-A1 PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS SCHERING CORPORATION (US) 2010-10-14 WO disclosed