Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8288 | 0.84 | MAOA (0.38) | ALDH1A1KDM4EHPGDLMNARYR2 | |
| SCHEMBL3619022 | 0.83 | ALDH1A1 (0.36) | ALDH1A1KDM4EHPGDLMNARYR2 | |
| SCHEMBL6542435 | 0.81 | CA2 (0.34) | ALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL6542401 | 0.79 | TRPA1 (0.39) | ALDH1A1KDM4EHPGDLMNARYR2 | |
| SCHEMBL7984059 | 0.78 | TRPA1 (0.38) | ALDH1A1KDM4EHPGDLMNARYR2 | |
| SCHEMBL7974791 | 0.75 | BCHE (0.38) | ALDH1A1LMNA | |
| Pyrrole SCHEMBL11735098 | 0.75 | ALDH1A1 (0.32) | ALDH1A1KDM4EHPGDGAA | |
| SCHEMBL7382465 | 0.72 | ALDH1A1 (0.37) | ALDH1A1KDM4EHPGDLMNARYR2 | |
| SCHEMBL4103011 | 0.72 | ALDH1A1 (0.37) | ALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL3081411 | 0.71 | ALDH1A1 (0.38) | ALDH1A1KDM4EHPGDLMNARYR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037929-B1 | 2-amino-thiazole derivatives, process for their preparation, and their use as antitumor agents | PHARMACIA & UPJOHN S.P.A. (IT) | 2006-05-02 | — | — | US | disclosed |
| EP-1124810-B9 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-12-28 | — | — | EP | disclosed |
| EP-1124810-B1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-05-04 | — | — | EP | disclosed |
| EP-1124810-A1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.p.A. (IT) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000026202-A1 | 2-AMINO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA & UPJOHN S.P.A. (IT) | 2000-05-11 | — | — | WO | disclosed |