Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837768 | 0.86 | ALDH1A1 (0.45) | ALDH1A1TSHRGAAMEN1KMT2A | |
| SCHEMBL5838589 | 0.83 | CXCR2 (0.37) | ALDH1A1TSHRGAAMEN1KMT2A | |
| SCHEMBL5838538 | 0.83 | CXCR2 (0.37) | ALDH1A1TSHR | |
| SCHEMBL6318443 | 0.79 | ALDH1A1 (0.45) | ALDH1A1TSHRGAAMEN1KMT2A | |
| SCHEMBL5837565 | 0.78 | GPR119 (0.33) | ALDH1A1TSHR | |
| SCHEMBL6315172 | 0.78 | ALDH1A1 (0.45) | ALDH1A1TSHRGAAMEN1KMT2A | |
| SCHEMBL5837370 | 0.78 | PTPN1 (0.45) | ALDH1A1TSHRGAAMEN1KMT2A | |
| SCHEMBL5837569 | 0.78 | CXCR2 (0.42) | ALDH1A1KMT2A | |
| SCHEMBL5837692 | 0.77 | PTPN1 (0.42) | ALDH1A1TSHRGAAMEN1KMT2A | |
| SCHEMBL6314950 | 0.77 | CXCR2 (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | disclosed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | disclosed |
| EP-1214325-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |