Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5839221 | 0.89 | ADORA1 (0.36) | GPR119 | |
| SCHEMBL5838631 | 0.87 | PTPN1 (0.37) | GPR119ALDH1A1TSHR | |
| SCHEMBL5838083 | 0.81 | CXCR2 (0.31) | CXCR2 | |
| SCHEMBL5846957 | 0.80 | GPR119 (0.33) | GPR119ALDH1A1TSHR | |
| SCHEMBL5837378 | 0.78 | ALDH1A1 (0.44) | ALDH1A1TSHR | |
| SCHEMBL5838538 | 0.77 | CXCR2 (0.37) | ALDH1A1TSHRCXCR2MAPT | |
| SCHEMBL5838589 | 0.77 | CXCR2 (0.37) | ALDH1A1TSHRCXCR2MAPTRXFP1 | |
| SCHEMBL5837569 | 0.71 | CXCR2 (0.42) | ALDH1A1CXCR2MAPT | |
| SCHEMBL5838393 | 0.70 | CXCR2 (0.41) | ALDH1A1CXCR2MAPT | |
| SCHEMBL5839226 | 0.69 | ADORA1 (0.35) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |