Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GHSR | Q92847 | 5/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 9/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837554 | 0.87 | ADORA1 (0.40) | KEAP1NFE2L2ADORA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5838602 | 0.84 | ADORA1 (0.36) | GHSRHTTADORA1ALDH1A1LMNA | |
| SCHEMBL5838374 | 0.78 | GHSR (0.40) | GHSRHTTKEAP1SMN1; SMN2LMNA | |
| SCHEMBL7519817 | 0.78 | ADORA1 (0.42) | GHSRADORA1ALDH1A1LMNAKLK7 | |
| SCHEMBL5837175 | 0.76 | TPSAB1 (0.39) | ADORA1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5837464 | 0.76 | ADORA1 (0.35) | GHSRHTTADORA1LMNA | |
| SCHEMBL5768500 | 0.74 | GRM6 (0.37) | KEAP1NFE2L2ADORA1LMNA | |
| SCHEMBL5769847 | 0.74 | GRM6 (0.37) | KEAP1NFE2L2ADORA1LMNA | |
| SCHEMBL5768503 | 0.74 | GRM6 (0.37) | KEAP1NFE2L2ADORA1LMNA | |
| SCHEMBL5838338 | 0.74 | ALDH1A1 (0.32) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |
| EP-1214324-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001019830-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | disclosed |