Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.33 |
| ▸ | SLC9A3 | P48764 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5837418 | 1.00 | CA1 (0.35) | CA1CA2MAOBMAOAALDH1A1 | |
| SCHEMBL5837425 | 1.00 | CA1 (0.35) | CA1CA2MAOBMAOAALDH1A1 | |
| SCHEMBL5837598 | 1.00 | CA1 (0.35) | CA1CA2MAOBMAOAALDH1A1 | |
| SCHEMBL5837014 | 1.00 | CA1 (0.35) | CA1CA2MAOBMAOAALDH1A1 | |
| SCHEMBL18995717 | 0.87 | PDPK1 (0.39) | CA1CA2MAOBMAOAALDH1A1 | |
| SCHEMBL12719520 | 0.87 | NTRK1 (0.40) | CA1CA2MAOBMAOAALDH1A1 | |
| SCHEMBL1943014 | 0.82 | MTNR1A (0.40) | ALDH1A1MEN1KMT2AGRM7 | |
| SCHEMBL1943012 | 0.82 | MTNR1A (0.40) | ALDH1A1MEN1KMT2AGRM7 | |
| SCHEMBL1943017 | 0.82 | MTNR1A (0.40) | ALDH1A1MEN1KMT2AGRM7 | |
| SCHEMBL5375159 | 0.81 | HDAC3 (0.38) | CA1CA2MAOBMAOASLC9A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7138415-B2 | Indolamid derivatives which possess glycogenphosphorylase inhibitory activity | ASTRAZENECA AB (SE) | 2006-11-21 | — | — | US | disclosed |
| US-20050107362-A1 | Indolamid derivatives which possess glycogenphosphorylase inhibitory activity | ASTRA ZENECA AB (SE) | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107362-A1 | Indolamid derivatives which possess glycogenphosphorylase inhibitory activity | PYGL, PYGM, PYGB | CA1 1491/4885CA2 322/4885MAOB 979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.