Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.35 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7550192 | 0.95 | AKR1C2 (0.38) | AKR1C2MTNR1AMTNR1BHDAC1MEN1 | |
| SCHEMBL5838311 | 0.90 | AKR1C2 (0.39) | AKR1C2MTNR1AMTNR1BHDAC1MAPT | |
| SCHEMBL5837745 | 0.88 | PTPN1 (0.44) | AKR1C2MTNR1AMTNR1BHDAC1MEN1 | |
| SCHEMBL5838160 | 0.82 | ALDH1A1 (0.43) | NT5EMEN1MAPTKMT2AKDM4E | |
| SCHEMBL7521561 | 0.80 | NT5E (0.43) | NT5EMEN1MAPTKMT2ATDP1 | |
| SCHEMBL7555860 | 0.79 | AKR1C2 (0.37) | AKR1C2MTNR1AMTNR1BHDAC1MEN1 | |
| SCHEMBL7520923 | 0.77 | THRB (0.40) | NT5EMEN1MAPTKMT2APTPN1 | |
| SCHEMBL7519646 | 0.76 | NT5E (0.42) | NT5EMEN1KMT2ATDP1PTPN1 | |
| SCHEMBL5838298 | 0.73 | KDM4E (0.40) | NT5EMAPTHTTTDP1PTPN1 | |
| SCHEMBL5837927 | 0.72 | NT5E (0.40) | NT5ETDP1PTPN1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115624-B1 | Method of inhibiting protein tyrosine phosphatase 1B and/or T-cell protein tyrosine phosphatase 4 and/or other PTPases with an Asp residue at position 48 | NOVO NORDISK A/S (DK) | 2006-10-03 | — | — | US | disclosed |
| EP-1214324-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2006-06-14 | — | — | EP | disclosed |
| US-6410556-B1 | ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2002-06-25 | — | — | US | disclosed |