Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.55 |
| ▸ | RXRB | P28702 | 4/20 | 0.55 |
| ▸ | RXRG | P48443 | 4/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 8/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5839649 | 0.85 | LMNA (0.59) | RXRARXRBRXRGMRGPRX4LMNA | |
| SCHEMBL2451483 | 0.80 | RXRA (0.58) | RXRARXRBRXRGMRGPRX4LMNA | |
| SCHEMBL2453780 | 0.79 | NR4A2 (0.62) | MRGPRX4HTTALDH1A1MAPTL3MBTL1 | |
| SCHEMBL2452574 | 0.79 | LMNA (0.68) | LMNANPC1ALDH1A1HPGDFOLH1 | |
| SCHEMBL28758280 | 0.78 | NPC1 (0.56) | RXRARXRBRXRGMRGPRX4LMNA | |
| SCHEMBL23673335 | 0.78 | KMT2A (0.54) | RXRARXRBRXRGMRGPRX4HTT | |
| SCHEMBL5839135 | 0.78 | ALDH1A1 (0.53) | RXRARXRBRXRGMRGPRX4HTT | |
| SCHEMBL5839505 | 0.77 | MRGPRX4 (0.59) | MRGPRX4HTTALDH1A1HPGD | |
| SCHEMBL5838725 | 0.77 | MRGPRX4 (0.53) | RXRARXRBRXRGMRGPRX4LMNA | |
| SCHEMBL2453382 | 0.77 | LMNA (0.62) | MRGPRX4LMNANPC1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984645-B2 | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-01-10 | — | — | US | disclosed |