Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.56 |
| ▸ | RXRA | P19793 | 1/20 | 0.52 |
| ▸ | RXRB | P28702 | 1/20 | 0.52 |
| ▸ | RXRG | P48443 | 1/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.47 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.47 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2447727 | 0.85 | RXRA (0.63) | MRGPRX4RXRARXRBRXRGALDH1A1 | |
| SCHEMBL5839266 | 0.84 | FFAR1 (0.56) | MRGPRX4ALDH1A1CTSVCTSLPTGER1 | |
| SCHEMBL1388008 | 0.83 | MRGPRX4 (0.59) | MRGPRX4ALDH1A1PTGER1 | |
| SCHEMBL2453780 | 0.82 | NR4A2 (0.62) | MRGPRX4ALDH1A1FFAR1NR4A2 | |
| SCHEMBL27436417 | 0.81 | MRGPRX4 (0.53) | MRGPRX4RXRARXRBRXRGKDM5A | |
| SCHEMBL3375496 | 0.80 | MRGPRX4 (0.62) | MRGPRX4MAPK14MMP2MMP9MMP14 | |
| SCHEMBL9138058 | 0.80 | KDM4E (0.51) | KDM5AKDM4CKDM5BALDH1A1MAPK14 | |
| SCHEMBL2453382 | 0.80 | LMNA (0.62) | MRGPRX4ALDH1A1PTGER1FOLH1NR4A2 | |
| SCHEMBL12189462 | 0.79 | MRGPRX4 (0.53) | MRGPRX4 | |
| SCHEMBL112903 | 0.79 | SGMS2 (0.66) | ALDH1A1PTGER1FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984645-B2 | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-01-10 | — | — | US | disclosed |