Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 1/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.46 |
| ▸ | TUBB | P07437 | 4/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.46 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.46 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5840652 | 1.00 | CCNB2 (0.51) | CCNB2CDK1CCNB1CCNB3PTGS2 | |
| SCHEMBL5815215 | 0.85 | TUBB1 (0.60) | CCNB2CDK1CCNB1CCNB3TUBB1 | |
| SCHEMBL28950285 | 0.82 | PTGS2 (0.66) | CCNB2CDK1CCNB1CCNB3PTGS2 | |
| SCHEMBL30140493 | 0.82 | PTGS2 (0.66) | CCNB2CDK1CCNB1CCNB3PTGS2 | |
| SCHEMBL5839385 | 0.82 | PAX8 (0.44) | CCNB2CDK1CCNB1CCNB3TUBB1 | |
| SCHEMBL5839375 | 0.82 | PAX8 (0.44) | CCNB2CDK1CCNB1CCNB3TUBB1 | |
| SCHEMBL11014243 | 0.82 | ATM (0.51) | CCNB2CDK1CCNB1CCNB3TUBB1 | |
| SCHEMBL5840734 | 0.82 | TUBB1 (0.66) | CCNB2CDK1CCNB1CCNB3PTGS2 | |
| SCHEMBL9273100 | 0.75 | CCNB2 (0.69) | CCNB2CDK1CCNB1CCNB3PTGS2 | |
| SCHEMBL353879 | 0.74 | HTT (0.47) | PTGS2KDM4ECYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135502-B1 | Colchinol derivatives as vascular damaging agents | ANGIOGENE PHARMACEUTICALS LTD. (GB) | 2006-11-14 | — | — | US | disclosed |
| EP-1140745-B1 | COLCHINOL DERIVATIVES AS VASCULAR DAMAGING AGENTS | ANGIOGENE PHARM LTD (GB) | 2003-10-22 | — | — | EP | disclosed |