Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL8992010 | 0.95 | LMNA (1.00) | — | |
| Succinic Acid SCHEMBL4269130 | 0.95 | LMNA (1.00) | — | |
| Succinic Acid SCHEMBL829 | 0.95 | — | — | |
| Succinic Acid SCHEMBL24696 | 0.95 | LMNA (1.00) | — | |
| Succinic Acid SCHEMBL4269135 | 0.95 | LMNA (1.00) | — | |
| Succinic Acid SCHEMBL29808469 | 0.95 | — | — | |
| Succinic Acid SCHEMBL3799615 | 0.95 | — | — | |
| Succinic Acid SCHEMBL1331200 | 0.95 | — | — | |
| Succinic Acid SCHEMBL21867134 | 0.95 | LMNA (1.00) | — | |
| Succinic Acid SCHEMBL1331252 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11213530-B2 | Gallium in the treatment of coronavirus disease | BERNSTEIN LAWRENCE RICHARD (US) | 2022-01-04 | — | — | US | claimed |
| WO-2021258086-A2 | GALLIUM IN THE TREATENT OF CORONAVIRUS DISEASE | BERNSTEIN LAWRENCE (US) | 2021-12-23 | — | — | WO | claimed |
| US-20210275544-A1 | Gallium in the treatment of coronavirus disease | BERNSTEIN LAWRENCE RICHARD (US) | 2021-09-09 | — | — | US | claimed |
| US-20190255100-A1 | TREATMENT OF CARDIOVASCULAR DISEASE BY USING GALLIUM COMPOUNDS TO BIND CALCIFIED LESIONS | LIPIDRISK, LLC | 2019-08-22 | — | — | US | claimed |
| US-9616133-B2 | Orally administrable gallium compositions and methods of use | BERNSTEIN LAWRENCE R (US) | 2017-04-11 | — | — | US | claimed |
| US-20160317669-A1 | ORALLY ADMINISTRABLE GALLIUM COMPOSITIONS AND METHODS OF USE | BERNSTEIN LAWRENCE R (US) | 2016-11-03 | — | — | US | claimed |
| EP-2099464-B1 | LOCAL ADMINISTRATION OF GALLIUM COMPOSITIONS TO TREAT PAIN | BERNSTEIN LAWRENCE RICHARD (US) | 2016-05-25 | — | — | EP | claimed |
| US-9205108-B2 | Treatment of traumatic brain injury by using gallium compounds to reduce oxidative stress levels | TROUP JAN M (US) | 2015-12-08 | — | — | US | claimed |
| US-20150306138-A1 | TREATMENT OF TRAUMATIC BRAIN INJURY BY USING GALLIUM COMPOUNDS TO REDUCE OXIDATIVE STRESS LEVELS | TROUP JAN M (US) | 2015-10-29 | — | — | US | claimed |
| US-9114067-B2 | Local administration of gallium compositions to treat pain | BERNSTEIN LAWRENCE RICHARD (US) | 2015-08-25 | — | — | US | claimed |
| EP-1996211-A1 | GALLIUM COMPOSITIONS FOR THE TREATMENT OF LIVER CANCER AND METHODS OF USE | BERNSTEIN, Lawrence Richard (US) | 2008-12-03 | — | — | EP | claimed |
| US-20080292726-A1 | OPHTHALMIC GALLIUM COMPOSITIONS AND METHODS OF THEIR USE | BERNSTEIN LAWRENCE R | 2008-11-27 | — | — | US | claimed |
| EP-1993567-A2 | ORALLY ADMINISTRABLE GALLIUM COMPOSITIONS AND METHOD OF USE | BERNSTEIN, Lawrence Richard (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2008091829-A1 | OPHTHALMIC GALLIUM COMPOSITIONS AND METHODS OF THEIR USE | BERNSTEIN LAWRENCE (US) | 2008-07-31 | — | — | WO | claimed |
| US-20080175922-A1 | Ophthalmic gallium compositions and methods of their use | BERNSTEIN LAWRENCE R | 2008-07-24 | — | — | US | claimed |
| WO-2008058210-A2 | LOCAL ADMINISTRATION OF GALLIUM COMPOSITIONS TO TREAT PAIN | BERNSTEIN LAWRENCE R (US) | 2008-05-15 | — | — | WO | claimed |
| US-20080113004-A1 | Gallium complex; pain, itching, allodynia, hyperalgesia, peripheral neuropathic pain associated with postherpetic neuralgia. | BERNSTEIN LAWRENCE R | 2008-05-15 | — | — | US | claimed |
| WO-2008036429-A1 | GALLIUM COMPOSITIONS FOR THE TREATMENT OF LIVER CANCER AND METHODS OF USE | BERNSTEIN LAWRENCE R (US) | 2008-03-27 | — | — | WO | claimed |
| WO-2007100382-A2 | ORALLY ADMINISTRABLE GALLIUM COMPOSITIONS AND METHOD OF USE | BERNSTEIN LAWRENCE R (US) | 2007-09-07 | — | — | WO | claimed |
| US-20070098815-A1 | Orally Administrable Gallium Compositions and Methods of Use | BERNSTEIN LAWRENCE R | 2007-05-03 | — | — | US | claimed |