Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 6/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL5841357 | 1.00 | HTR7 (0.49) | HTR7SIGMAR1ABCB1HTR6TSHR | |
| SCHEMBL6983212 | 0.92 | HTR7 (0.57) | HTR7SIGMAR1ABCB1HTR6 | |
| Fumaric Acid SCHEMBL5842610 | 0.86 | HTR7 (0.47) | HTR7SIGMAR1ABCB1HTR6TSHR | |
| Fumaric Acid SCHEMBL5842607 | 0.86 | HTR7 (0.47) | HTR7SIGMAR1ABCB1HTR6TSHR | |
| Fumaric Acid SCHEMBL5842117 | 0.79 | HTR7 (0.74) | HTR7SIGMAR1ABCB1HTR6TSHR | |
| Fumaric Acid SCHEMBL5842113 | 0.79 | HTR7 (0.74) | HTR7SIGMAR1ABCB1HTR6TSHR | |
| Fumaric Acid SCHEMBL5841757 | 0.77 | HTR7 (0.59) | HTR7ABCB1HTR6TSHRHTT | |
| Fumaric Acid SCHEMBL5842459 | 0.77 | HTR7 (0.55) | HTR7SIGMAR1ABCB1HTR6TSHR | |
| Fumaric Acid SCHEMBL5841750 | 0.77 | HTR7 (0.59) | HTR7ABCB1HTR6TSHRHTT | |
| Fumaric Acid SCHEMBL5842464 | 0.77 | HTR7 (0.55) | HTR7SIGMAR1ABCB1HTR6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992085-B2 | Octahydro-2H-pyrido[1,2-a]pyrazine compounds | LES LABORATORIES SERVIER (FR) | 2006-01-31 | — | — | US | disclosed |
| US-20030195216-A1 | Octahydro-2H-pyrido[1,2-a] pyrazine compounds | LES LABORATOIRES SERVIER (FR) | 2003-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195216-A1 | Octahydro-2H-pyrido[1,2-a] pyrazine compounds | CYP2W1, OXER1, IL1R1 | HRH3 308/4885HTR7 410/4885SIGMAR1 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.