SCHEMBL5841377

SCHEMBL5841377

O=CNc1cc[nH]c(=O)n1

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.32
DYRK1A Q13627 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4306636 0.82 DYRK1A (0.31) DYRK1AADORA2AADORA1
SCHEMBL2830187 0.80 ADORA2A (0.33) DYRK1AADORA2AADORA1
SCHEMBL21961537 0.76 APP (0.42) ALDH1A1DYRK1AADORA2AADORA1
SCHEMBL29752139 0.74 NPC1 (0.36) ALDH1A1DYRK1A
SCHEMBL3133642 0.74
SCHEMBL5985571 0.74
SCHEMBL7876670 0.74
SCHEMBL8944768 0.74
N4-Hydroxycytosine SCHEMBL48396 0.74
SCHEMBL19692379 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 512 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12422415-B2 Analytical methods of assessing cytisine purity ACHIEVE LIFE SCIENCES, INC. 2025-09-23 US claimed
US-20250101494-A1 METHODS FOR ANALYZING CYTOSINE METHYLATION AND HYDROXYMETHYLATION GUARDANT HEALTH, INC. 2025-03-27 US claimed
WO-2025054389-A1 IDENTIFICATION OF METHYLATED CYTOSINE USING LANDMARKS ILLUMINA, INC. (US) 2025-03-13 WO claimed
WO-2025024123-A1 NOVEL CITICOLINE DERIVATIVES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-01-30 WO claimed
EP-4486911-A1 METHODS FOR ANALYZING CYTOSINE METHYLATION AND HYDROXYMETHYLATION Guardant Health, Inc. (US) 2025-01-08 EP claimed
EP-4399517-A1 ANALYTICAL METHODS OF ASSESSING CYTISINE PURITY Achieve Life Sciences, Inc. (US) 2024-07-17 EP claimed
US-20240124942-A1 MARKERS OF PREDICTION OF RESPONSE TO CAR T CELL THERAPY FUNDACIÓ INSTITUT DE RECERCA CONTRA LA LEUCÈMIA JOSEP CARRERAS (ES) 2024-04-18 US claimed
EP-4298250-A1 MARKERS OF PREDICTION OF RESPONSE TO CAR T CELL THERAPY Fundació Institut de Recerca Contra la Leucèmia Josep Carreras (ES) 2024-01-03 EP claimed
WO-2023168300-A1 METHODS FOR ANALYZING CYTOSINE METHYLATION AND HYDROXYMETHYLATION GUARDANT HEALTH, INC. (US) 2023-09-07 WO claimed
WO-2023038931-A9 ANALYTICAL METHODS OF ASSESSING CYTISINE PURITY ACHIEVE LIFE SCIENCES, INC. (US) 2023-06-15 WO claimed
WO-2018172726-A1 SINGLE CELL DNA SEQUENCING BLACKTRACE HOLDINGS LIMITED (GB) 2018-09-27 WO claimed
EP-3368688-A1 COMPOSITIONS AND METHODS FOR DETERMINING MODIFIED CYTOSINES BY SEQUENCING New England Biolabs, Inc. (US) 2018-09-05 EP claimed
EP-3307755-A1 IDENTIFICATION OF GENETIC MODIFICATIONS Wake Forest University Health Sciences (US) 2018-04-18 EP claimed
US-20170198344-A1 Compositions and Methods for Analyzing Modified Nucleotides NEW ENGLAND BIOLABS, INC. (US) 2017-07-13 US claimed
WO-2017075436-A1 COMPOSITIONS AND METHODS FOR DETERMINING MODIFIED CYTOSINES BY SEQUENCING NEW ENGLAND BIOLABS, INC. (US) 2017-05-04 WO claimed
EP-3157573-A2 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF Moderna Therapeutics, Inc. (US) 2017-04-26 EP claimed
US-20160333340-A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID AMPLIFICATION Twist Bioscience Corporation 2016-11-17 US claimed
WO-2016183289-A1 IDENTIFICATION OF GENETIC MODIFICATIONS WAKE FOREST UNIVERSITY HEALTH SERVICES (US) 2016-11-17 WO claimed
WO-2016183100-A1 COMPOSITIONS AND METHODS FOR NUCLEIC ACID AMPLIFICATION Twist Bioscience Corporation (US) 2016-11-17 WO claimed
WO-2015196128-A2 ALTERNATIVE NUCLEIC ACID MOLECULES AND USES THEREOF MODERNA THERAPEUTICS, INC. (US) 2015-12-23 WO claimed