Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | RPA1 | P27694 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1772679 | 0.81 | ALDH1A1 (0.84) | ALDH1A1HPGDRPA1NR4A1NR4A2 | |
| SCHEMBL4896906 | 0.80 | ALDH1A1 (0.66) | ALDH1A1HPGDNR4A2KDM4EMAPT | |
| SCHEMBL3744237 | 0.79 | ALDH1A1 (0.64) | ALDH1A1HPGDPIM1RPA1NR4A1 | |
| SCHEMBL22042133 | 0.78 | SCN10A (0.62) | SCN10APIM1PTGER4AURKATPX2 | |
| Hydrochloric Acid SCHEMBL10434191 | 0.78 | ALDH1A1 (0.62) | ALDH1A1HPGDPIM1RPA1NR4A1 | |
| SCHEMBL3417241 | 0.78 | ALDH1A1 (0.67) | ALDH1A1HPGDPIM1RPA1NR4A1 | |
| SCHEMBL26264367 | 0.76 | SUCNR1 (0.71) | SCN10A | |
| SCHEMBL26263250 | 0.76 | SUCNR1 (0.62) | SCN10AKDM4EMAPT | |
| SCHEMBL3054179 | 0.76 | ALDH1A1 (0.70) | ALDH1A1HPGDRPA1NR4A1NR4A2 | |
| SCHEMBL7138575 | 0.75 | ALDH1A1 (0.65) | ALDH1A1HPGDNR4A1NR4A2NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109243-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2006-09-19 | — | — | US | claimed |
| US-7109243-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2006-09-19 | — | — | US | disclosed |
| WO-2004084842-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |
| US-20040198780-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040198780-A1 | Inhibitors of cathepsin S | CTSS, CTSK, CTSE | SCN10A 2264/4885ALDH1A1 4380/4885HPGD 2181/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.