Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5842238 | 0.87 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL5843962 | 0.85 | SMN1; SMN2 (0.69) | ALDH1A1SMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL6613455 | 0.83 | NPC1 (0.45) | ALDH1A1SMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL5841926 | 0.82 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL5844160 | 0.82 | SMN1; SMN2 (0.56) | ALDH1A1SMN1; SMN2KMT2AHPGDHTT | |
| SCHEMBL5841681 | 0.81 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL5841684 | 0.81 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL5841935 | 0.81 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL5842543 | 0.80 | SMN1; SMN2 (0.55) | ALDH1A1SMN1; SMN2KMT2ALMNANPC1 | |
| SCHEMBL5842182 | 0.79 | NPSR1 (0.48) | ALDH1A1SMN1; SMN2KMT2ALMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109243-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2006-09-19 | — | — | US | disclosed |
| US-7067549-B2 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2006-06-27 | — | — | US | disclosed |
| US-20050192292-A1 | Pyrrolidone carboxamides | ACTELION PHARMACEUTICALS AG (CH) | 2005-09-01 | — | — | US | disclosed |
| US-20040198780-A1 | Inhibitors of cathepsin S | IRM LLC (BM) | 2004-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050192292-A1 | Pyrrolidone carboxamides | NPY1R, NPY5R, NPY2R | ALDH1A1 3034/4885SMN1; SMN2 3678/4885KMT2A 3347/4885 |
| US-20040198780-A1 | Inhibitors of cathepsin S | CTSS, CTSK, CTSE | ALDH1A1 4380/4885SMN1; SMN2 3203/4885KMT2A 3983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.