Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560790 | 0.78 | HTT (0.47) | L3MBTL1ALDH1A1MAPTPOLBTDP1 | |
| SCHEMBL8560783 | 0.78 | HTT (0.47) | L3MBTL1ALDH1A1MAPTPOLBTDP1 | |
| SCHEMBL25244867 | 0.78 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL8485479 | 0.78 | ALDH1A1 (0.47) | L3MBTL1ALDH1A1MAPTPOLBTDP1 | |
| SCHEMBL27491805 | 0.78 | HDAC1 (0.51) | ALDH1A1POLBPKMGAA | |
| SCHEMBL892946 | 0.78 | HDAC1 (0.51) | ALDH1A1POLBPKMGAA | |
| SCHEMBL9042235 | 0.78 | L3MBTL1 (0.60) | L3MBTL1ALDH1A1MAPTPOLBTDP1 | |
| Bromide SCHEMBL7887350 | 0.74 | L3MBTL1 (0.43) | L3MBTL1ALDH1A1MAPTPOLBTDP1 | |
| SCHEMBL13120844 | 0.73 | ALDH1A1 (0.46) | L3MBTL1ALDH1A1MAPTPOLBTDP1 | |
| SCHEMBL14303528 | 0.73 | HRH3 (0.48) | L3MBTL1ALDH1A1MAPTPKMKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109243-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2006-09-19 | — | — | US | claimed |
| US-7109243-B2 | Inhibitors of cathepsin S | IRM LLC (BM) | 2006-09-19 | — | — | US | disclosed |
| WO-2004084842-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2004-10-07 | — | — | WO | disclosed |