Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GRM8 | O00222 | 1/20 | 0.43 |
| ▸ | GRM6 | O15303 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.43 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10773163 | 0.89 | GRM2 (0.37) | GRM2GRM3GRM4CYP2C19CYP1A2 | |
| SCHEMBL16635848 | 0.80 | SLC6A12 (0.38) | GRM4CYP2C19CYP1A2TDP1GRM8 | |
| SCHEMBL28710315 | 0.76 | TSHR (0.48) | GRM2GRM3GRM4CYP2C19CYP1A2 | |
| SCHEMBL583655 | 0.76 | ALOX15 (0.44) | GRM2GRM3GRM4CYP2C19CYP1A2 | |
| SCHEMBL583582 | 0.70 | LMNA (0.39) | GRM2GRM3GRM4CYP2C19CYP1A2 | |
| SCHEMBL31119101 | 0.68 | ALOX15 (0.40) | GRM2GRM3GRM4CYP2C19CYP1A2 | |
| SCHEMBL30148894 | 0.68 | GRM2 (0.37) | GRM2GRM3GRM4CYP2C19CYP1A2 | |
| SCHEMBL6120873 | 0.68 | CYP1A2 (0.43) | GRM2GRM3CYP2C19CYP1A2ALOX15 | |
| SCHEMBL18204574 | 0.67 | TSHR (0.42) | GRM2GRM3GRM4CYP2C19CYP1A2 | |
| SCHEMBL4019338 | 0.67 | TSHR (0.42) | GRM2GRM3GRM4CYP2C19CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417138-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | Schering Corporation (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |