Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 14/20 | 0.44 |
| ▸ | MMP9 | P14780 | 9/20 | 0.44 |
| ▸ | MMP1 | P03956 | 9/20 | 0.44 |
| ▸ | MMP2 | P08253 | 6/20 | 0.44 |
| ▸ | MMP14 | P50281 | 2/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.41 |
| ▸ | ME2 | P23368 | 1/20 | 0.39 |
| ▸ | ME1 | P48163 | 1/20 | 0.39 |
| ▸ | ME3 | Q16798 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 2/20 | 0.38 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.38 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5846699 | 0.97 | S1PR1 (0.49) | S1PR1MMP13MMP9MMP1MMP2 | |
| SCHEMBL5848378 | 0.92 | MMP13 (0.44) | S1PR1MMP13MMP9MMP1MMP2 | |
| Hydrochloric Acid SCHEMBL5717397 | 0.90 | MMP13 (0.50) | MMP13MMP9MMP1MMP2MMP14 | |
| Hydrochloric Acid SCHEMBL5841394 | 0.87 | MMP13 (0.49) | S1PR1MMP13MMP9MMP1MMP2 | |
| SCHEMBL6097144 | 0.81 | MMP13 (0.60) | MMP13MMP9MMP1MMP2MMP14 | |
| SCHEMBL5840188 | 0.81 | MMP13 (0.40) | S1PR1MMP13MMP9MMP1MMP2 | |
| SCHEMBL5845551 | 0.80 | MMP9 (0.43) | MMP13MMP9MMP1MMP2MMP14 | |
| SCHEMBL5841309 | 0.79 | MMP13 (0.40) | S1PR1MMP13MMP9MMP1MMP2 | |
| SCHEMBL8292881 | 0.78 | MMP13 (0.47) | MMP13MMP9MMP1MMP2MMP14 | |
| SCHEMBL5717533 | 0.77 | MMP13 (0.47) | MMP13MMP9MMP1MMP2MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119203-B2 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors | PHARMACIA CORPORATION (US) | 2006-10-10 | — | — | US | disclosed |
| US-20050209278-A1 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors | PHARMACIA CORPORATION | 2005-09-22 | — | — | US | disclosed |
| US-20050009838-A1 | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors | PHARMACIA CORPORATION | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209278-A1 | Piperidinyl- and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors | MMP1, PREP, MMP3 | S1PR1 2285/4885MMP13 6/4885MMP9 5/4885 |
| US-20050009838-A1 | Piperidinyl-and piperazinyl-sulfonylmethyl hydroxamic acids and their use as protease inhibitors | MMP1, PREP, MMP3 | S1PR1 2285/4885MMP13 6/4885MMP9 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.