Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.47 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.47 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.47 |
| ▸ | CHIT1 | Q13231 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL9333894 | 1.00 | TSHR (0.61) | TSHRPDK1PDK2PDK3PDK4 | |
| Trifluoroacetic Acid SCHEMBL3556372 | 0.89 | TSHR (0.48) | TSHRPDK1PDK2PDK3PDK4 | |
| Trifluoroacetic Acid SCHEMBL29059043 | 0.83 | NPC1 (0.44) | TSHRCHIT1HSD17B10TP53SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL584210 | 0.83 | MAPT (0.49) | CES1SMN1; SMN2HDAC1HDAC7HDAC8 | |
| Trifluoroacetic Acid SCHEMBL27939406 | 0.83 | ALOX5 (0.48) | TSHRPDK1PDK2PDK3PDK4 | |
| Trichloroacetic Acid SCHEMBL3973964 | 0.83 | TSHR (0.61) | TSHRPDK1PDK2PDK3PDK4 | |
| Trifluoroacetic Acid SCHEMBL11500234 | 0.82 | CHIT1 (0.42) | TSHRPDK1PDK2PDK3PDK4 | |
| Diphenylamine SCHEMBL31175857 | 0.82 | HSD17B10 (0.57) | TSHRCES1HSD17B10SMN1; SMN2L3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL21177989 | 0.82 | EPHX2 (0.46) | TSHRTP53EPHX2SMN1; SMN2KIF11 | |
| Trifluoroacetic Acid SCHEMBL28860217 | 0.82 | TRPV1 (0.47) | TSHRHSD17B10TP53HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 268 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114644602-B | Preparation method of dihydro isoxazole compound | 帕潘纳(北京)科技有限公司 | 2024-09-03 | — | — | CN | claimed |
| US-20200131431-A1 | CHEMICAL ADDITIVES AND SURFACTANT COMBINATIONS FOR FAVORABLE WETTABILITY ALTERATION AND IMPROVED HYDROCARBON RECOVERY FACTORS | ALCHEMY SCIENCES INC (US) | 2020-04-30 | — | — | US | claimed |
| US-7709169-B2 | Charge trapping releaser containing charge transport layer photoconductors | XEROX CORPORATION (US) | 2010-05-04 | — | — | US | claimed |
| US-7687212-B2 | Charge trapping releaser containing photogenerating layer photoconductors | XEROX CORPORATION (US) | 2010-03-30 | — | — | US | claimed |
| US-20090092909-A1 | CHARGE TRAPPING RELEASER CONTAINING PHOTOGENERATING LAYER PHOTOCONDUCTORS | XEROX CORPORATION (US) | 2009-04-09 | — | — | US | claimed |
| US-20090092908-A1 | CHARGE TRAPPING RELEASER CONTAINING CHARGE TRANSPORT LAYER PHOTOCONDUCTORS | XEROX CORPORATION (US) | 2009-04-09 | — | — | US | claimed |
| US-7235660-B1 | Facile process for the preparation of high-purity aminopterin | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2007-06-26 | — | — | US | claimed |
| US-6372030-B1 | INK VEHICLE SELECTED FROM 4-(HEXADECYLAMINO)BENZYLAMINE, N-OCTANOYL-N-METHYL GLUCAMINE, OCTANOIC HYDRAZIDE, 4-HEXADECYL SULFONYL ANILINE, A CONDUCTIVE COMPLEX OF AN AMINE COMPOUND WITH A PHOSPHORUS OR SULFUR-CONTAINING ACID | XEROX CORPORATION | 2002-04-16 | — | — | US | claimed |
| EP-0225823-B1 | PROCESS FOR THE PREPARATION OF PTERIDINE DERIVATIVES | RHONE-POULENC SANTE (FR) | 1990-01-31 | — | — | EP | claimed |
| US-4767859-A | Process for the preparation of pteridine derivatives | RHONE-POULENC SANTE (FR) | 1988-08-30 | — | — | US | claimed |
| US-12540144-B2 | Rapafucin derivative compounds and methods of use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2026-02-03 | — | — | US | disclosed |
| CN-116102510-B | Preparation method of 3-bromo-5, 5-dimethyl-4, 5-dihydro-isoxazole | 江西仰立新材料有限公司 | 2025-03-25 | — | — | CN | disclosed |
| CN-113891882-B | Process for producing dihydroisoxazole | 组合化学工业株式会社 | 2024-11-26 | — | — | CN | disclosed |
| CN-114644602-B | Preparation method of dihydro isoxazole compound | 帕潘纳(北京)科技有限公司 | 2024-09-03 | — | — | CN | disclosed |
| US-20240239810-A1 | RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2024-07-18 | — | — | US | disclosed |
| EP-0127143-B1 | NOVEL ARYLOXYCYCLOALKANOLAMINOALKYLENE ARYL KETONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-21 | — | — | EP | disclosed |
| US-4868315-A | HYPOTENSIVE AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-19 | — | — | US | disclosed |
| US-4767859-A | Process for the preparation of pteridine derivatives | RHONE-POULENC SANTE (FR) | 1988-08-30 | — | — | US | disclosed |
| US-4745222-A | HYPOTENSIVE AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-05-17 | — | — | US | disclosed |
| EP-0127143-A2 | Novel aryloxycycloalkanolaminoalkylene aryl ketones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-12-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12540144-B2 | Rapafucin derivative compounds and methods of use thereof | RICTOR, CHP1, FKBP8 | TSHR 2134/4885PDK1 4530/4885PDK2 4560/4885 |
| US-20240239810-A1 | RAPAFUCIN DERIVATIVE COMPOUNDS AND METHODS OF USE THEREOF | RICTOR, MTOR, FKBP14 | TSHR 4022/4885PDK1 1870/4885PDK2 1959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.