Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9519060 | 0.89 | ADRA2C (0.37) | ADRA2CPTGS2HRH1HTR3APDE4D | |
| Hydrochloric Acid SCHEMBL6250502 | 0.78 | ADRA2C (0.39) | ADRA2CPTGS2HRH1HTR3APDE4D | |
| SCHEMBL2232629 | 0.77 | ADRA2C (0.37) | ADRA2CPTGS2HRH1HTR3APDE4D | |
| SCHEMBL22879574 | 0.76 | ADRA2C (0.40) | ADRA2CPTGS2HRH1HTR3APDE4D | |
| SCHEMBL2231523 | 0.76 | ADRA2C (0.40) | ADRA2CPTGS2HRH1HTR3APDE4D | |
| SCHEMBL6251581 | 0.76 | ADRA2C (0.36) | ADRA2CPTGS2HRH1HTR3APDE4D | |
| SCHEMBL9250186 | 0.76 | ALDH1A1 (0.39) | ADRA2CPTGS2HRH1HTR3APDE4D | |
| SCHEMBL2231743 | 0.73 | ADRA2C (0.59) | ADRA2CPTGS2HRH1HTR3APDE4D | |
| SCHEMBL6251445 | 0.71 | ADRA2C (0.37) | ADRA2CPTGS2HRH1HTR3APDE4D | |
| SCHEMBL5844394 | 0.71 | ADRA2C (0.37) | ADRA2CPTGS2HRH1HTR3APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7094847-B2 | Metallocene compounds and use thereof in catalysts for the polymerization of olefins | BASELL TECHNOLOGY COMPANY B.V. (NL) | 2006-08-22 | — | — | US | claimed |
| EP-0702687-A1 | METALLOCENE COMPOUNDS AND USE THEREOF IN CATALYSTS FOR THE POLYMERIZATION OF OLEFINS | Montell Technology Company bv (NL) | 1996-03-27 | — | — | EP | claimed |
| WO-1995027717-A1 | METALLOCENE COMPOUNDS AND USE THEREOF IN CATALYSTS FOR THE POLYMERIZATION OF OLEFINS | MONTELL TECHNOLOGY COMPANY BV (NL) | 1995-10-19 | — | — | WO | claimed |
| US-7094847-B2 | Metallocene compounds and use thereof in catalysts for the polymerization of olefins | BASELL TECHNOLOGY COMPANY B.V. (NL) | 2006-08-22 | — | — | US | disclosed |
| US-20010012877-A1 | Metallocene compounds and use thereof in catalysts for the polymerization of olefins | MONTELL TECHNOLOGY COMPANY B.V. | 2001-08-09 | — | — | US | disclosed |