Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.57 |
| ▸ | ALPL | P05186 | 2/20 | 0.49 |
| ▸ | ALPG | P10696 | 2/20 | 0.49 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.49 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.49 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.49 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845732 | 0.81 | BCHE (0.60) | BCHEALPLALPGPLAATRPC3 | |
| SCHEMBL5844227 | 0.81 | ITGB3 (0.47) | BCHEALPLALPGPLAARAB9A | |
| SCHEMBL8328333 | 0.80 | ALPL (0.64) | BCHEALPLALPGPLAATRPC3 | |
| SCHEMBL5846138 | 0.80 | KCNH2 (0.60) | BCHEALPLALPGPLAATRPC3 | |
| SCHEMBL7217435 | 0.78 | BCHE (0.60) | BCHEALPLALPGPLAATRPC3 | |
| SCHEMBL16866616 | 0.77 | BCHE (0.55) | BCHEALPLALPGPLAATRPC3 | |
| SCHEMBL6764617 | 0.76 | BCHE (0.65) | BCHEALPLALPGPLAATRPC3 | |
| SCHEMBL13049808 | 0.74 | BCHE (0.66) | BCHETRPC3TRPC4TRPC5KCNH2 | |
| SCHEMBL17329389 | 0.73 | BCHE (0.57) | BCHEALPLALPGPLAATRPC3 | |
| SCHEMBL5844930 | 0.72 | BCHE (0.67) | BCHEALPLALPGPLAATRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135587-B2 | Urea and urethane derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2006-11-14 | — | — | US | disclosed |
| EP-1343764-B1 | UREA AND URETHANE DERIVATIVES AS INTEGRIN INHIBITORS | MERCK PATENT GMBH (DE) | 2004-08-25 | — | — | EP | disclosed |
| US-20040063644-A1 | Urea and urethane derivatives as integrin inhibitors | MERCK PATENT GMBH (DE) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063644-A1 | Urea and urethane derivatives as integrin inhibitors | ITGB1, ITGB2, ITGA1 | BCHE 3836/4885ALPL 3246/4885ALPG 3535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.