SCHEMBL5846101

SCHEMBL5846101

C1=C(c2ccccc2)CCN(CCCCn2cnc3ccccc32)C1

nearest known ligand 0.56

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 2/20 0.56
DRD4 P21917 2/20 0.56
DRD3 P35462 2/20 0.56
P2RX7 Q99572 1/20 0.56
SIGMAR1 Q99720 2/20 0.55
SMN1; SMN2 Q16637 4/20 0.52
LMNA P02545 2/20 0.52
ALOX15 P16050 1/20 0.52
TSHR P16473 1/20 0.52
PARP1 P09874 3/20 0.50
TDP1 Q9NUW8 1/20 0.50
HTT P42858 2/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5846883 0.99 DRD2 (0.55) DRD2DRD4DRD3P2RX7SIGMAR1
SCHEMBL6161263 0.92 SMN1; SMN2 (0.57) DRD2DRD4DRD3P2RX7SIGMAR1
SCHEMBL5846929 0.91 SIGMAR1 (0.55) DRD2DRD4DRD3P2RX7SIGMAR1
Hydrochloric Acid SCHEMBL5847007 0.90 SIGMAR1 (0.54) DRD2DRD4DRD3P2RX7SIGMAR1
SCHEMBL5846846 0.83 TDP1 (0.51) SIGMAR1PARP1TDP1
SCHEMBL6161437 0.83 SIGMAR1 (0.55) SIGMAR1PARP1
Dimethylamine SCHEMBL7353096 0.80 PARP1 (0.51) SIGMAR1PARP1
SCHEMBL7360497 0.80 NPC1 (0.48) SIGMAR1SMN1; SMN2KMT2A
Hydrochloric Acid SCHEMBL7058366 0.80 SIGMAR1 (0.54) SIGMAR1PARP1
Dimethylamine SCHEMBL7352059 0.80 PARP1 (0.50) SIGMAR1ALOX15TSHRPARP1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39113-E1 Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain LABORATORIES DEL DR. ESTEVE, S.A. (ES) 2006-05-30 US claimed
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
US-6384055-B1 ANALGESICS LABORATORIOS DEL DR. ESTEVES, S.A. (ES) 2002-05-07 US claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP disclosed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP disclosed
US-6232329-B1 POSSESSING THERAPEUTIC ACTIVITY FOR THE TREATMENT OF ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSION, MOTORICITY PROBLEMS, AMNESIA, CEREBROVASCULAR DISEASES OR SENILE DEMENTIA LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-15 US disclosed
US-5731331-A Tetrahydropyridine-(or 4-hydroxypiperidine) alkylazoles LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1998-03-24 US disclosed