SCHEMBL6161437

SCHEMBL6161437

C1=C(c2ccccc2)CCN(CCCCn2cnc(-c3ccccc3)c2-c2ccccc2)C1

nearest known ligand 0.55

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.55
PRKD3 O94806 1/20 0.51
MAP4K4 O95819 1/20 0.51
FRK P42685 1/20 0.51
MAPK9 P45984 1/20 0.51
CSNK1A1 P48729 1/20 0.51
CSNK1D P48730 1/20 0.51
GSK3B P49841 1/20 0.51
PRKD2 Q9BZL6 1/20 0.51
MAP4K5 Q9Y4K4 1/20 0.51
PARP1 P09874 3/20 0.47
HTR1A P08908 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5846101 0.83 DRD2 (0.56) SIGMAR1PARP1
Hydrochloric Acid SCHEMBL5846883 0.82 DRD2 (0.55) SIGMAR1PARP1
Hydrochloric Acid SCHEMBL7058366 0.80 SIGMAR1 (0.54) SIGMAR1PARP1HTR1A
SCHEMBL5846853 0.77 SIGMAR1 (0.59) SIGMAR1PARP1HTR1A
SCHEMBL6844082 0.76 MAPK13 (0.69)
SCHEMBL6847089 0.76 PRKD3 (0.54) PRKD3MAP4K4FRKMAPK9CSNK1A1
SCHEMBL6162058 0.76 SIGMAR1 (0.60) SIGMAR1HTR1A
Hydrochloric Acid SCHEMBL6163489 0.76 SIGMAR1 (0.58) SIGMAR1PARP1HTR1A
SCHEMBL8419683 0.76 PRKD3 (0.54) PRKD3MAP4K4FRKMAPK9CSNK1A1
SCHEMBL6161263 0.75 SMN1; SMN2 (0.57) SIGMAR1PARP1HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
US-6232329-B1 POSSESSING THERAPEUTIC ACTIVITY FOR THE TREATMENT OF ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSION, MOTORICITY PROBLEMS, AMNESIA, CEREBROVASCULAR DISEASES OR SENILE DEMENTIA LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-15 US claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed
WO-1996004287-A1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1996-02-15 WO claimed