SCHEMBL6161263

SCHEMBL6161263

Cc1ccc(C2=CCN(CCCCn3cnc4ccccc43)CC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 6/20 0.57
HTT P42858 4/20 0.56
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
SIGMAR1 Q99720 3/20 0.54
PARP1 P09874 1/20 0.52
DRD2 P14416 2/20 0.50
DRD4 P21917 2/20 0.50
DRD3 P35462 2/20 0.50
P2RX7 Q99572 1/20 0.50
HTR1A P08908 1/20 0.48
LMNA P02545 4/20 0.48
MAPT P10636 2/20 0.48
STAT3 P40763 1/20 0.48
CYP11B1 P15538 1/20 0.48
CYP11B2 P19099 1/20 0.48
TDP1 Q9NUW8 1/20 0.47
ALOX15 P16050 1/20 0.46
TSHR P16473 1/20 0.46
KDM4E B2RXH2 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5846101 0.92 DRD2 (0.56) SMN1; SMN2HTTMEN1KMT2ASIGMAR1
Hydrochloric Acid SCHEMBL5846883 0.91 DRD2 (0.55) SMN1; SMN2HTTMEN1KMT2ASIGMAR1
SCHEMBL5846929 0.90 SIGMAR1 (0.55) SMN1; SMN2HTTSIGMAR1PARP1DRD2
Hydrochloric Acid SCHEMBL5847007 0.89 SIGMAR1 (0.54) SMN1; SMN2HTTMEN1KMT2ASIGMAR1
SCHEMBL5846846 0.83 TDP1 (0.51) SIGMAR1PARP1HTR1ATDP1
SCHEMBL15748184 0.78 DRD2 (0.77) SMN1; SMN2HTTMEN1KMT2ADRD2
Dimethylamine SCHEMBL7353096 0.78 PARP1 (0.51) SIGMAR1PARP1
Dimethylamine SCHEMBL7352059 0.77 PARP1 (0.50) SIGMAR1PARP1TDP1ALOX15TSHR
SCHEMBL7353085 0.76 PARP1 (0.47) SIGMAR1PARP1HTR1A
SCHEMBL6161437 0.75 SIGMAR1 (0.55) SIGMAR1PARP1HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed
WO-1996004287-A1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1996-02-15 WO claimed