Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3982415 | 0.83 | NOS3 (0.50) | — | |
| SCHEMBL25698026 | 0.81 | NOS3 (0.45) | POLB | |
| SCHEMBL5846563 | 0.79 | EPHX2 (0.42) | GRIN1EPHX2 | |
| Hydrochloric Acid SCHEMBL28729781 | 0.79 | SIGMAR1 (0.48) | — | |
| SCHEMBL652510 | 0.78 | TRPA1 (0.51) | POLBRAB9ASMN1; SMN2TRPA1GRIN1 | |
| SCHEMBL5755254 | 0.76 | CTSD (0.40) | POLBRAB9ASMN1; SMN2TRPA1GRIN1 | |
| SCHEMBL2370080 | 0.76 | POLB (0.51) | POLBRAB9ASMN1; SMN2TRPA1 | |
| SCHEMBL14394798 | 0.76 | POLB (0.51) | POLBRAB9ASMN1; SMN2TRPA1 | |
| SCHEMBL3634313 | 0.73 | EPHX2 (0.48) | TRPA1GRIN1EPHX2 | |
| SCHEMBL29114052 | 0.73 | NOS3 (0.41) | POLBRAB9ASMN1; SMN2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7126010-B2 | Benzylcycloalkyl amines as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2006-10-24 | — | — | US | disclosed |
| US-20050124671-A1 | Benzylcycloalkyl amines as modulators of chemokine receptor activity | WACKER DEAN A (US) | 2005-06-09 | — | — | US | disclosed |
| US-6864380-B2 | Benzylcycloalkyl amines as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-03-08 | — | — | US | disclosed |
| US-20040014758-A1 | Benzylcycloalkyl amines as modulators of chemokine receptor activity | WACKER DEAN A (US) | 2004-01-22 | — | — | US | disclosed |
| US-6608227-B1 | Prevention of inflammatory diseases such as asthma and other allergic diseases | BRISTOL-MYERS SQUIBB PHARMA | 2003-08-19 | — | — | US | disclosed |
| EP-1220836-A2 | BENZYLCYCLOALKYL AMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Pharma Company (US) | 2002-07-10 | — | — | EP | disclosed |
| WO-2001028987-A1 | BENZYLCYCLOALKYL AMINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2001-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014758-A1 | Benzylcycloalkyl amines as modulators of chemokine receptor activity | CCR3, CCR1, CCR10 | HCRTR1 267/4885HCRTR2 571/4885POLB 3376/4885 |
| US-20050124671-A1 | Benzylcycloalkyl amines as modulators of chemokine receptor activity | CCR3, CCR1, CCR10 | HCRTR1 322/4885HCRTR2 513/4885POLB 3296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.