Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 14/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | S100A4 | P26447 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18079823 | 0.81 | HTR1A (0.46) | PDK2ALDH1A1TSHRMAPK1 | |
| SCHEMBL18079828 | 0.81 | HTR1A (0.46) | PDK2ALDH1A1TSHRMAPK1 | |
| SCHEMBL17903056 | 0.81 | HTR1A (0.46) | PDK2ALDH1A1TSHRMAPK1 | |
| SCHEMBL26999776 | 0.81 | PDK2 (0.43) | PDK2ALDH1A1TSHRKDM4EMAPK1 | |
| SCHEMBL23097228 | 0.81 | PDK2 (0.38) | PDK2S100A4MAPK1 | |
| SCHEMBL5487698 | 0.81 | PDK2 (0.42) | PDK2ALDH1A1TSHRLMNAMAPT | |
| SCHEMBL5846726 | 0.81 | PDK2 (0.63) | PDK2TSHRLMNAMAPTSMN1; SMN2 | |
| SCHEMBL23655327 | 0.81 | PDK2 (0.61) | PDK2ALDH1A1TRPA1LMNAMAPT | |
| SCHEMBL16995983 | 0.80 | HTR7 (0.47) | PDK2ALDH1A1TSHRKMT2A | |
| SCHEMBL4258846 | 0.78 | MEN1 (0.57) | PDK2ALDH1A1TRPA1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7088757-B1 | Use of spiro compounds as laser dyes | SEMICONDUCTORS GMBH (DE) | 2006-08-08 | — | — | US | disclosed |
| US-6822094-B2 | AMORPHOUS SPIROBIFLUORENE COMPOUND USED IN A PHOTOVOLTIC CELL AS CHARGE TRANSPORTING MATERIAL | AVENTIS RESEARCH & TECHNOLOGIES, GMBH & CO. KG (DE) | 2004-11-23 | — | — | US | disclosed |
| EP-0935691-B1 | OPTICAL BRIGHTENING AGENT | COVION ORGANIC SEMICONDUCTORS (DE) | 2004-05-26 | — | — | EP | disclosed |
| US-20030111107-A1 | Spiro compounds and their use | MERCK OLED MATERIALS GMBH (DE) | 2003-06-19 | — | — | US | disclosed |
| EP-0676461-B1 | Spiro compounds and their application as electroluminescence materials | COVION ORGANIC SEMICONDUCTORS (DE) | 2002-08-14 | — | — | EP | disclosed |
| EP-1053578-B1 | USE OF SPIRO COMPOUNDS AS LASER DYES | COVION ORGANIC SEMICONDUCTORS (DE) | 2002-05-08 | — | — | EP | disclosed |
| EP-0968175-B1 | SPIRO COMPOUNDS AND THE USE THEREOF | CELANESE VENTURES GMBH (DE) | 2001-12-12 | — | — | EP | disclosed |
| US-6187224-B1 | ORGANIC SPIRO COMPOUNDS WHICH COMPRISE A CONJUGATED SYSTEM | AXIVA GMBH (DE) | 2001-02-13 | — | — | US | disclosed |
| EP-1053578-A1 | USE OF SPIRO COMPOUNDS AS LASER DYES | Axiva GmbH (DE) | 2000-11-22 | — | — | EP | disclosed |
| EP-0968175-A1 | SPIRO COMPOUNDS AND THE USE THEREOF | Aventis Research & Technologies GmbH & Co KG (DE) | 2000-01-05 | — | — | EP | disclosed |
| EP-0935691-A1 | OPTICAL BRIGHTENING AGENT | Aventis Research & Technologies GmbH & Co. KG (DE) | 1999-08-18 | — | — | EP | disclosed |
| WO-1999040655-A1 | USE OF SPIRO COMPOUNDS AS LASER DYES | AXIVA GMBH (DE) | 1999-08-12 | — | — | WO | disclosed |
| US-5840217-A | LIGHT-EMITTING, CHARGE-TRANSPORT, CHARGE-INJECTION MATERIALS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-11-24 | — | — | US | disclosed |
| WO-1998042655-A1 | SPIRO COMPOUNDS AND THE USE THEREOF | AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO KG (DE) | 1998-10-01 | — | — | WO | disclosed |
| WO-1998018996-A1 | OPTICAL BRIGHTENING AGENT | AVENTIS RESEARCH & TECHNOLOGIES GMBH & CO KG (DE) | 1998-05-07 | — | — | WO | disclosed |
| EP-0676461-A2 | Spiro compounds and their application as electroluminescence materials | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-10-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030111107-A1 | Spiro compounds and their use | PKD1, PKD2, REN | PDK2 478/4885ALDH1A1 54/4885TRPA1 230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.