Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 7/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5849715 | 0.88 | DRD1 (0.37) | CCR3HCRTR1HCRTR2KDM5A | |
| SCHEMBL5848598 | 0.85 | TSHR (0.33) | CCR3NOTUM | |
| SCHEMBL5847854 | 0.85 | HCRTR1 (0.36) | CCR3HCRTR1HCRTR2 | |
| SCHEMBL5848396 | 0.83 | CCR3 (0.31) | CCR3 | |
| SCHEMBL5847107 | 0.83 | SCD5 (0.37) | CCR3HCRTR1HCRTR2SCD5 | |
| SCHEMBL5847193 | 0.82 | CCR3 (0.35) | CCR3 | |
| SCHEMBL5848064 | 0.82 | DPP4 (0.36) | CCR3 | |
| SCHEMBL5418700 | 0.81 | HCRTR1 (0.38) | CCR3HCRTR1HCRTR2HSD11B1 | |
| SCHEMBL5847121 | 0.80 | CCR3 (0.35) | CCR3HSD11B1NOTUM | |
| SCHEMBL5421544 | 0.79 | CCR3 (0.33) | CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | claimed |
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |