Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.30 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.30 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.30 |
| ▸ | DPP4 | P27487 | 2/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5848064 | 0.89 | DPP4 (0.36) | CCR3DPP4DPP7 | |
| SCHEMBL5848396 | 0.87 | CCR3 (0.31) | CCR3 | |
| SCHEMBL5847392 | 0.85 | CCR3 (0.34) | CCR3NOTUM | |
| SCHEMBL5847854 | 0.85 | HCRTR1 (0.36) | LMNAHTR2AHTR2CCCR3DPP4 | |
| SCHEMBL5847193 | 0.84 | CCR3 (0.35) | FKBP1AHTR2AHTR2CCCR3 | |
| SCHEMBL5849715 | 0.84 | DRD1 (0.37) | TSHRHTR2AHTR2CCCR3DPP4 | |
| SCHEMBL5847107 | 0.81 | SCD5 (0.37) | HTR2AHTR2CCCR3DPP4DPP7 | |
| SCHEMBL5421544 | 0.80 | CCR3 (0.33) | CCR3 | |
| SCHEMBL5847913 | 0.79 | ABCB1 (0.35) | FKBP1AHTR2CCCR3 | |
| SCHEMBL5847121 | 0.79 | CCR3 (0.35) | HTR2AHTR2CCCR3NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | claimed |
| US-7081455-B2 | Substituted heterocycle fused gamma-carbolines | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-25 | — | — | US | disclosed |