SCHEMBL6162324

SCHEMBL6162324

Fc1ccc(C2=CCN(CCCCn3cc(Cl)cn3)CC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 9/20 0.57
DRD2 P14416 1/20 0.55
PARP1 P09874 3/20 0.48
KCNH2 Q12809 1/20 0.46
PARP2 Q9UGN5 1/20 0.46
HTR7 P34969 3/20 0.45
MAPK1 P28482 1/20 0.45
HTR1A P08908 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7115716 0.99 SIGMAR1 (0.56) SIGMAR1DRD2PARP1KCNH2PARP2
SCHEMBL5846267 0.92 SIGMAR1 (0.60) SIGMAR1DRD2PARP1HTR7HTR1A
Hydrochloric Acid SCHEMBL6165778 0.91 SIGMAR1 (0.59) SIGMAR1DRD2PARP1HTR7HTR1A
SCHEMBL5847759 0.89 SIGMAR1 (0.56) SIGMAR1DRD2PARP1HTR7HTR1A
SCHEMBL5847491 0.88 SIGMAR1 (0.58) SIGMAR1DRD2PARP1HTR1A
SCHEMBL5846299 0.86 SIGMAR1 (0.55) SIGMAR1DRD2PARP1HTR1A
SCHEMBL5846180 0.85 SIGMAR1 (0.59) SIGMAR1PARP1HTR1A
SCHEMBL5848161 0.84 SIGMAR1 (0.60) SIGMAR1PARP1HTR1A
SCHEMBL8010714 0.82 SIGMAR1 (0.72) SIGMAR1DRD2PARP1HTR7MAPK1
SCHEMBL6161845 0.81 HTR7 (0.54) SIGMAR1PARP1HTR7HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0721455-B9 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2005-04-20 EP claimed
EP-1097698-B1 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN ESTEVE LABOR DR (ES) 2003-05-07 EP claimed
EP-0721455-B1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS ESTEVE LABOR DR (ES) 2002-12-11 EP claimed
US-6232329-B1 POSSESSING THERAPEUTIC ACTIVITY FOR THE TREATMENT OF ANXIETY, PSYCHOSIS, EPILEPSY, CONVULSION, MOTORICITY PROBLEMS, AMNESIA, CEREBROVASCULAR DISEASES OR SENILE DEMENTIA LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-15 US claimed
EP-1097698-A2 UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 2001-05-09 EP claimed
WO-1996004287-A1 TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS LABORATORIOS DEL DR. ESTEVE, S.A. (ES) 1996-02-15 WO claimed