Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.57 |
| ▸ | CDK4 | P11802 | 3/20 | 0.56 |
| ▸ | CCND1 | P24385 | 3/20 | 0.56 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.51 |
| ▸ | CCR3 | P51677 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.49 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.49 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30298382 | 0.81 | DRD2 (0.63) | SIGMAR1P2RX7CDK4CCND1DRD2 | |
| SCHEMBL3990196 | 0.79 | CDK4 (0.73) | SIGMAR1P2RX7CDK4CCND1DRD2 | |
| SCHEMBL9776119 | 0.78 | CDK4 (0.74) | SIGMAR1P2RX7CDK4CCND1DRD2 | |
| SCHEMBL5847565 | 0.78 | DRD2 (0.59) | SIGMAR1P2RX7DRD2DRD4DRD3 | |
| SCHEMBL30298377 | 0.78 | DRD2 (0.59) | SIGMAR1P2RX7CDK4CCND1DRD2 | |
| SCHEMBL5847154 | 0.78 | P2RX7 (0.59) | SIGMAR1P2RX7DRD2OPRL1CCR3 | |
| SCHEMBL9776034 | 0.76 | CDK4 (0.72) | SIGMAR1P2RX7CDK4CCND1DRD2 | |
| SCHEMBL3989584 | 0.76 | CDK4 (0.73) | SIGMAR1P2RX7CDK4CCND1DRD2 | |
| SCHEMBL9370237 | 0.76 | SIGMAR1 (0.72) | SIGMAR1DRD2OPRL1CCR3MEN1 | |
| SCHEMBL15578543 | 0.75 | CDK4 (0.67) | SIGMAR1P2RX7CDK4CCND1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39113-E1 | Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2006-05-30 | — | — | US | claimed |
| EP-0721455-B9 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2005-04-20 | — | — | EP | claimed |
| CN-1120167-C | Tetrahydropyridine-(or 4-hydroxypiperidine) Alkylazoles having an affinity for sigma and/or 5HTIA receptors | ESTEVE S A LAB DE DR (ES) | 2003-09-03 | — | — | CN | claimed |
| EP-1097698-B1 | UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN | ESTEVE LABOR DR (ES) | 2003-05-07 | — | — | EP | claimed |
| EP-0721455-B1 | TETRAHYDROPYRIDINE-(OR 4-HYDROXYPIPERIDINE)ALKYLAZOLES HAVING AN AFFINITY FOR SIGMA AND/OR 5HT1A RECEPTORS | ESTEVE LABOR DR (ES) | 2002-12-11 | — | — | EP | claimed |
| EP-1097698-A2 | UTILIZATION OF DERIVATIVES OF TETRAHYDROPYRIDINES (OR 4-HYDROXYPIPERIDINES)-BUTYLAZOLS IN THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2001-05-09 | — | — | EP | claimed |
| CN-1166173-A | Tetrahydropyridine- (or 4-hydroxypiperidine) alkylpyrroles active at sigma and/or 5HTIA receptors | ESTEVE S A LAB DE DR (ES) | 1997-11-26 | — | — | CN | claimed |