Sugi Predict

Sugi Predict / Compounds / SCHEMBL584957

SCHEMBL584957

SCHEMBL584957

N#Cc1c(Br)cccc1CBr

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP1A1 P04798 2/20 0.39
▸ CYP1A2 P05177 2/20 0.39
▸ CYP1B1 Q16678 2/20 0.39
▸ DYRK1A Q13627 1/20 0.34
▸ TAAR1 Q96RJ0 3/20 0.33
▸ TLR8 Q9NR97 1/20 0.33
▸ IDO1 P14902 2/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ MAPT P10636 1/20 0.32
▸ GABRA1 P14867 1/20 0.32
▸ GABRB2 P47870 1/20 0.32
▸ TSHR P16473 1/20 0.32
▸ MAOB P27338 1/20 0.32
▸ CNR1 P21554 1/20 0.32
▸ CNR2 P34972 1/20 0.32
▸ LMNA P02545 2/20 0.31
▸ PRMT5 O14744 1/20 0.31
▸ WDR77 Q9BQA1 1/20 0.31
▸ SMN1; SMN2 Q16637 2/20 0.31
▸ GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2809185 0.87 CYP1A2 (0.39) CYP1A1CYP1A2CYP1B1ALDH1A1MAPT
SCHEMBL22904469 0.82 ALDH1A1 (0.38) CYP1A1CYP1A2CYP1B1DYRK1ATAAR1
SCHEMBL16960032 0.82 S1PR1 (0.39) CYP1A1CYP1A2CYP1B1DYRK1ATAAR1
SCHEMBL29735277 0.82 GABRA1 (0.50) CYP1A1CYP1A2CYP1B1DYRK1ATAAR1
SCHEMBL29909691 0.82 ALDH1A1 (0.38) CYP1A1CYP1A2CYP1B1DYRK1ATAAR1
SCHEMBL14115760 0.82 GABRA1 (0.50) CYP1A1CYP1A2CYP1B1DYRK1ATAAR1
SCHEMBL1343169 0.79 DYRK1A (0.42) CYP1A1CYP1A2CYP1B1DYRK1ATLR8
SCHEMBL1125092 0.79 SMN1; SMN2 (0.37) CYP1A1CYP1A2CYP1B1ALDH1A1MAPT
SCHEMBL16949914 0.78 KDM4E (0.40) CYP1A1CYP1A2CYP1B1TAAR1ALDH1A1
SCHEMBL22660214 0.78 DYRK1A (0.37) CYP1A1CYP1A2CYP1B1DYRK1ATAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230143612-A1 SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME ARBUTUS BIOPHARMA CORP (US) 2023-05-11 — — US disclosed
EP-4100381-A1 SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME Arbutus Biopharma Corporation (CA) 2022-12-14 — — EP disclosed
CN-115413275-A Substituted 1,1 , -biphenyl compounds and methods of use thereof 爱彼特生物制药公司 2022-11-29 — — CN disclosed
WO-2021158481-A1 SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME ARBUTUS BIOPHARMA, INC. (US) 2021-08-12 — — WO disclosed
US-20120077989-A1 CYCLIC IMIDATE LIGANDS UNIVERSITEIT GENT (BE) 2012-03-29 — — US disclosed
US-20120077989-A1 CYCLIC IMIDATE LIGANDS UNIVERSITEIT GENT (BE) 2012-03-29 — — US disclosed
EP-2416879-A1 CYCLIC IMIDATE LIGANDS Universiteit Gent (BE) 2012-02-15 — — EP disclosed
WO-2010115903-A1 CYCLIC IMIDATE LIGANDS UNIVERSITEIT GENT (BE) 2010-10-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120077989-A1 CYCLIC IMIDATE LIGANDS IDH2, CYCS, NAPRT CYP1A1 2984/4885CYP1A2 2197/4885CYP1B1 3319/4885
US-20230143612-A1 SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME HAVCR2, HMBS, VHL CYP1A1 21/4885CYP1A2 206/4885CYP1B1 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.