Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | AHR | P35869 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21539523 | 0.85 | GPR84 (0.47) | GPR84MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL7029009 | 0.81 | GPR84 (0.49) | GPR84MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL27301362 | 0.79 | ADAM17 (0.50) | GPR84MEN1KMT2AMAPTATM | |
| SCHEMBL28864004 | 0.77 | ATM (0.52) | GPR84MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL18933165 | 0.76 | ATM (0.41) | GPR84MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL13611510 | 0.76 | GPR84 (0.47) | GPR84MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL14694211 | 0.75 | ATM (0.50) | GPR84MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL7022975 | 0.75 | ATM (0.50) | GPR84MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL29611302 | 0.74 | HTR2A (0.47) | GPR84MEN1KMT2ACYP3A4MAPT | |
| SCHEMBL273916 | 0.74 | HTR2A (0.47) | GPR84MEN1KMT2ACYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060211759-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2006-09-21 | — | — | US | disclosed |
| US-7084166-B2 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA-TAU INDUSTRIE FARMACEUTICHEE RIUNITE S.P.A. (IT) | 2006-08-01 | — | — | US | disclosed |
| US-20040053987-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2004-03-18 | — | — | US | disclosed |
| EP-1337511-A1 | BIS-HETEROCYCLIC COMPOUNDS WITH ANTITUMOUR AND CHEMOSENSITISING ACTIVITY | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002036561-A1 | BIS-HETEROCYCLIC COMPOUNDS WITH ANTITUMOUR AND CHEMOSENSITISING ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060211759-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | ABCC1, MCL1, DPYD | GPR84 2548/4885MEN1 580/4885KMT2A 3309/4885 |
| US-20040053987-A1 | Bis-heterocyclic compounds with antitumour and chemosensitising activity | ABCC1, TOP1, CHEK1 | GPR84 2438/4885MEN1 331/4885KMT2A 2952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.