Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7742363 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1AHRMAPTCHRM2 | |
| SCHEMBL16234253 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1AHRMAPTCHRM2 | |
| SCHEMBL29896219 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1AHRMAPTCHRM2 | |
| SCHEMBL2466203 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1AHRMAPTCHRM2 | |
| SCHEMBL1872051 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2L3MBTL1AHRMAPTCHRM2 | |
| SCHEMBL221865 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1AHRMAPTCHRM2 | |
| SCHEMBL28323893 | 0.78 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1AHRMAPTCHRM2 | |
| SCHEMBL17189971 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL1AHRCHRM2KDM4E | |
| SCHEMBL9969506 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL1AHRCHRM2BLM | |
| SCHEMBL5041519 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1AHRKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7026324-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-04-11 | — | — | US | disclosed |
| US-20040097730-A1 | Thrombin inhibitors | MERCK & CO., INC. | 2004-05-20 | — | — | US | disclosed |
| EP-1359913-A1 | THROMBIN INHIBITORS | Merck & Co., Inc. (US) | 2003-11-12 | — | — | EP | disclosed |
| WO-2002064140-A1 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097730-A1 | Thrombin inhibitors | F3, F2, SERPINC1 | SMN1; SMN2 4322/4885L3MBTL1 1262/4885AHR 3009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.