Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.33 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.30 |
| ▸ | HMGCR | P04035 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7284670 | 0.90 | TSHR (0.62) | TSHRALDH1A1TRPA1PTPN7HMGCR | |
| SCHEMBL7279691 | 0.88 | TSHR (0.61) | TSHRALDH1A1PTPN7HMGCR | |
| SCHEMBL28701951 | 0.86 | TSHR (0.65) | TSHRALDH1A1PTPN7HMGCR | |
| SCHEMBL8213043 | 0.86 | TSHR (0.65) | TSHRALDH1A1PTPN7HMGCR | |
| SCHEMBL5856184 | 0.85 | — | — | |
| SCHEMBL5857596 | 0.84 | — | — | |
| SCHEMBL30461109 | 0.84 | TSHR (0.50) | TSHRALDH1A1TRPA1PTPN7HMGCR | |
| SCHEMBL10804043 | 0.83 | TSHR (0.61) | TSHRALDH1A1TRPA1PTPN7HMGCR | |
| SCHEMBL6576796 | 0.81 | TSHR (0.73) | TSHRALDH1A1TRPA1PTPN7HMGCR | |
| SCHEMBL5872279 | 0.81 | TSHR (0.73) | TSHRALDH1A1TRPA1PTPN7HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144906-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-12-05 | — | — | US | disclosed |
| US-7030143-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-04-18 | — | — | US | disclosed |
| US-7022723-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-04-04 | — | — | US | disclosed |
| EP-1634876-A2 | Heterocyclic compounds for the treatment of hyperlipidemia agents | Nippon Shinyaku Co., Ltd. (JP) | 2006-03-15 | — | — | EP | disclosed |
| US-6998412-B2 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2006-02-14 | — | — | US | disclosed |
| US-20050009892-A1 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2005-01-13 | — | — | US | disclosed |
| US-20050009785-A1 | Heterocyclic compounds | KUWABARA KENJI (JP) | 2005-01-13 | — | — | US | disclosed |
| US-20040162325-A1 | Heterocyclic compounds | KUWABARA KENJI (JP) | 2004-08-19 | — | — | US | disclosed |
| US-20030166697-A1 | Heterocyclic compounds | NIPPON SHINYAKU CO., LTD. (JP) | 2003-09-04 | — | — | US | disclosed |
| EP-1295875-A1 | HETEROCYCLIC COMPOUNDS | Nippon Shinyaku Co., Ltd. (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-5563129-A | Hydroquinone derivatives and intermediates for production thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-08 | — | — | US | disclosed |
| US-5534639-A | Hydroquinone derivatives and intermediates for production thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-07-09 | — | — | US | disclosed |
| US-5436359-A | Hydroquinone derivatives and intermediates for production thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0560568-A2 | Hydroquinone derivatives and intermediates for production thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-09-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009785-A1 | Heterocyclic compounds | LIPC, GPR119, APOB | TSHR 1666/4885ALDH1A1 760/4885TRPA1 1337/4885 |
| US-20050009892-A1 | Heterocyclic compounds | GPR119, LIPC, LIPE | TSHR 2487/4885ALDH1A1 571/4885TRPA1 1277/4885 |
| US-20040162325-A1 | Heterocyclic compounds | LIPE, GPR119, LIPC | TSHR 2672/4885ALDH1A1 557/4885TRPA1 1795/4885 |
| US-20030166697-A1 | Heterocyclic compounds | LIPE, GPR119, LIPC | TSHR 2672/4885ALDH1A1 557/4885TRPA1 1795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.