Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | TPH1 | P17752 | 1/20 | 0.44 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 3/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL110394 | 0.85 | NPC1 (0.51) | ADORA2ATPH1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL10918669 | 0.77 | NPC1 (0.46) | ADORA2ATPH1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL11499234 | 0.76 | TPH1 (0.45) | ADORA2ATPH1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL5855691 | 0.75 | ADORA2A (0.48) | ADORA2ATPH1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL11493280 | 0.74 | CACNA1G (0.47) | ADORA2ATPH1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL12481069 | 0.74 | MAPK1 (0.53) | ADORA2ATPH1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL27632456 | 0.74 | NPC1 (0.46) | ADORA2ATPH1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL30332519 | 0.73 | NPC1 (0.49) | ADORA2ATPH1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL20773519 | 0.73 | NPC1 (0.49) | ADORA2ATPH1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL18584960 | 0.73 | NPC1 (0.56) | ADORA2ATPH1CACNA1GCACNA1HCACNA1I |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144899-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-12-05 | — | — | US | disclosed |
| US-7026324-B2 | Thrombin inhibitors | MERCK & CO., INC. (US) | 2006-04-11 | — | — | US | disclosed |
| US-20040097730-A1 | Thrombin inhibitors | MERCK & CO., INC. | 2004-05-20 | — | — | US | disclosed |
| US-20040073025-A1 | Thrombin inhibitors | MERCK SHARP & DOHME CORP. | 2004-04-15 | — | — | US | disclosed |
| US-6610701-B2 | For therapy and prophylaxis of blood coagulation and cardiovascular disorders | MERCK & CO., INC. | 2003-08-26 | — | — | US | disclosed |
| US-20020193398-A1 | Thrombin inhibitors | MERCK & CO., INC. | 2002-12-19 | — | — | US | disclosed |
| WO-2002064559-A2 | THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040097730-A1 | Thrombin inhibitors | F3, F2, SERPINC1 | ADORA2A 3049/4885TPH1 3659/4885CACNA1G 1299/4885 |
| US-20020193398-A1 | Thrombin inhibitors | F2, F3, TFPI | ADORA2A 3421/4885TPH1 1108/4885CACNA1G 1260/4885 |
| US-20040073025-A1 | Thrombin inhibitors | F2, F11, F10 | ADORA2A 3432/4885TPH1 1622/4885CACNA1G 2190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.