Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | TPMT | P51580 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5855321 | 0.88 | HDAC8 (0.43) | POLBNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5854471 | 0.84 | SMN1; SMN2 (0.35) | POLBGAANPC1ALDH1A1RAB9A | |
| Hydrochloric Acid SCHEMBL5854407 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL5855476 | 0.80 | POLB (0.36) | POLBTAS1R3TAS1R1TAS1R2GAA | |
| Hydrochloric Acid SCHEMBL5853198 | 0.79 | HDAC8 (0.40) | GAARAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5852996 | 0.78 | L3MBTL1 (0.33) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL5853495 | 0.77 | DHODH (0.39) | POLBNPC1RAB9ASMN1; SMN2THRB | |
| Hydrochloric Acid SCHEMBL5853657 | 0.75 | MEN1 (0.32) | ALDH1A1THRB | |
| Hydrochloric Acid SCHEMBL5853030 | 0.73 | LMNA (0.38) | GAARAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5853107 | 0.72 | THRB (0.34) | POLBTAS1R3TAS1R1TAS1R2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7037989-B2 | Copolymers of ethylene and/or α-olefins and vicinally disubstituted olefins | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2006-05-02 | — | — | US | disclosed |
| US-20040242814-A1 | COPOLYMERS OF ETHYLENE AND/OR ALPHA-OLEFINS AND VICINALLY DISUBSTITUTED OLEFINS | EXXONMOBIL CHEMICAL PATENTS INC. | 2004-12-02 | — | — | US | disclosed |